Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …

Cell polarity, the generation of cellular asymmetries, is necessary for diverse processes in
animal cells, such as cell migration, asymmetric cell division, epithelial barrier function, and …

Protein Ser/Thr phosphatase-1 (PP1) catalyzes the majority of eukaryotic protein
dephosphorylation reactions in a highly regulated and selective manner. Recent studies …

In celiac disease (CD) a T-cell–mediated response to gluten is mounted in genetically
predisposed individuals, resulting in a malabsorptive enteropathy histologically highlighted …

Abstract E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial
sheets. Through the homophilic association of E-Cadherin molecules expressed on …

The conventional pipeline for biomarker development involves a discovery phase, typically
conducted by mass spectrometry (MS), followed by validation and clinical application …

Signaling pathways are commonly organized through inducible protein-protein interactions,
mediated by adaptor proteins that link activated receptors to cytoplasmic effectors. However …

Tight and adherens junctions are specialized sites of cell-cell interaction in epithelia and
endothelia, and are involved in barrier, adhesion, and signaling functions. These functions …

Protein phosphorylation serves as a primary mechanism of signal transduction in the cells of
biological organisms. Technical advancements over the last several years in mass …

Cell polarity is a fundamental property of most animal cells and is critical during
development and for most cell and tissue functions. Epithelial cells are organized into apical …