Impact of the gut-lung axis on tuberculosis susceptibility and progression

A Enjeti, HD Sathkumara, A Kupz - Frontiers in Microbiology, 2023 - frontiersin.org
Tuberculosis (TB) has remained at the forefront of the global infectious disease burden for
centuries. Concerted global efforts to eliminate TB have been hindered by the complexity of …

[HTML][HTML] Unlocking therapeutic potential: Integration of drug repurposing and immunotherapy for various disease targeting

VA Pawar, A Tyagi, C Verma, KP Sharma… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Drug repurposing, also known as drug repositioning, entails the application of pre-approved
or formerly assessed drugs having potentially functional therapeutic amalgams for curing …

Modulation of the Meisenheimer complex metabolism of nitro-benzothiazinones by targeted C-6 substitution

F Keiff, FA Bernal, M Joch… - Communications …, 2024 - nature.com
Tuberculosis, caused by Mycobacterium tuberculosis, remains a major public health
concern, demanding new antibiotics with innovative therapeutic principles due to the …

Mycobacterium tuberculosis and Pulmonary Rehabilitation: From Novel Pharmacotherapeutic Approaches to Management of Post-Tuberculosis Sequelae

AD Meca, L Mititelu-Tarțău, M Bogdan… - Journal of personalized …, 2022 - mdpi.com
Tuberculosis (TB) is still a worldwide public health burden, as more than 1.3 million deaths
are expected to be reported in 2021. Even though almost 20 million patients have completed …

Identification of nitrofuranylchalcone tethered benzoxazole-2-amines as potent inhibitors of drug resistant Mycobacterium tuberculosis demonstrating bactericidal …

SK Sahoo, S Maddipatla, SNR Gajula… - Bioorganic & Medicinal …, 2022 - Elsevier
Ever increasing drug resistance has become an impeding threat that continues to hamper
effective tackling of otherwise treatable tuberculosis (TB). Such dismal situation necessitates …

Antimicrobial Resistance Levels of Non-Tuberculous Bacteria Isolates from Sputum of TB Patients in Ghana

PA Morgan, DO Ntiamoah, P Asare… - Infection and Drug …, 2024 - Taylor & Francis
Background Patients with tuberculosis (TB) often harbor diverse bacteria in their sputum,
including both commensal and opportunistic pathogens. This study aimed to characterize …

[HTML][HTML] Multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) among children: Where we stand now

K Chowdhury, R Ahmad, S Sinha, S Dutta, M Haque - Cureus, 2023 - ncbi.nlm.nih.gov
Drug-resistant tuberculosis (DR-TB) has continued to be a global health cataclysm. It is an
arduous condition to tackle but is curable with the proper choice of drug and adherence to …

Safety evaluation and bioassay-guided isolation of antimycobacterial compounds from Morella salicifolia root ethanolic extract

AI Marealle, E Innocent, K Andrae-Marobela… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Although the available medicines can cure almost all
tuberculosis drug-susceptible patients some problems including the emergence of multi …

Bioevaluation of quinoline‐4‐carbonyl derivatives of piperazinyl‐benzothiazinones as promising antimycobacterial agents

SK Sahoo, SNR Gajula, MN Ahmad, G Kaul… - Archiv der …, 2022 - Wiley Online Library
The quinoline moiety remains a privileged antitubercular (anti‐TB) pharmacophore,
whereas 8‐nitrobenzothiazinones are emerging potent antimycobacterial agents with two …

Recent Developments in Medicinal and In Silico Applications of Imidazopyridine Derivatives: Special Emphasis on Malaria, Trypanosomiasis, and Tuberculosis

SN Mali, A Pandey - Chemistry Africa, 2022 - Springer
People from low-income countries are increasingly affected by neglected communicable
diseases, and the health care system frequently overlooks their needs. Currently, these …