Understanding the role of the transcription factor Sp1 in ovarian cancer: from theory to practice

B Vellingiri, M Iyer, M Devi Subramaniam… - International journal of …, 2020 - mdpi.com
Ovarian cancer (OC) is one of the deadliest cancers among women contributing to high risk
of mortality, mainly owing to delayed detection. There is no specific biomarker for its …

Prominin2 drives ferroptosis resistance by stimulating iron export

CW Brown, JJ Amante, P Chhoy, AL Elaimy, H Liu… - Developmental cell, 2019 - cell.com
Ferroptosis, regulated cell death characterized by the iron-dependent accumulation of lethal
lipid reactive oxygen species, contributes to tissue homeostasis and numerous pathologies …

LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer

W Luo, J Wang, W Xu, C Ma, F Wan, Y Huang… - Cell death & …, 2021 - nature.com
Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and
development in bladder cancer. However, the underlying molecular mechanisms remain …

[HTML][HTML] Integrative single-cell RNA-seq and ATAC-seq analysis of human developmental hematopoiesis

AM Ranzoni, A Tangherloni, I Berest, SG Riva, B Myers… - Cell stem cell, 2021 - cell.com
Regulation of hematopoiesis during human development remains poorly defined. Here we
applied single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase …

New iron export pathways acting via holo-ferritin secretion

I Yanatori, F Kishi, S Toyokuni - Archives of Biochemistry and Biophysics, 2023 - Elsevier
Ferritin is a spherical nanocage protein for iron storage, composed of 24 light-or heavy-
polypeptide chain subunits. A single ferritin molecule can carry up to 4500 iron atoms in its …

ST3GAL5‐catalyzed gangliosides inhibit TGF‐β‐induced epithelial‐mesenchymal transition via TβRI degradation

J Zhang, G van Der Zon, J Ma, H Mei… - The EMBO …, 2023 - embopress.org
Epithelial‐mesenchymal transition (EMT) is pivotal in the initiation and development of
cancer cell metastasis. We observed that the abundance of glycosphingolipids (GSLs) …

[HTML][HTML] Cell membrane-anchored and tumor-targeted IL-12 T-cell therapy destroys cancer-associated fibroblasts and disrupts extracellular matrix in heterogenous …

J Hu, AJ Lazar, D Ingram, WL Wang… - … for immunotherapy of …, 2024 - ncbi.nlm.nih.gov
Background The extracellular matrix (ECM) and cancer-associated fibroblasts (CAFs) play
major roles in tumor progression, metastasis, and the poor response of many solid tumors to …

Protein biomarker discovery studies on urinary sEV fractions separated with UF-SEC for the first diagnosis and detection of recurrence in bladder cancer patients

S Jordaens, E Oeyen, H Willems, F Ameye… - Biomolecules, 2023 - mdpi.com
Urinary extracellular vesicles (EVs) are an attractive source of bladder cancer biomarkers.
Here, a protein biomarker discovery study was performed on the protein content of small …

Numerical analysis of gold coating based quasi D-shape dual core PCF SPR sensor

MB Hossain, TV Mahendiran, LF Abdulrazak… - Optical and Quantum …, 2020 - Springer
In this article, a Quasi D-Shape dual core Photonic Crystal Fiber Surface Plasmon
Resonance sensor is offered and numerically analyzed. The offered model is established …

Role of DNA methylation profiles as potential biomarkers and novel therapeutic targets in head and neck cancer

K Burkitt - Cancers, 2023 - mdpi.com
Simple Summary Recent studies have shown that DNA methylation alters gene expression,
which drives tumorigenesis in cancer, and also, increasing evidence has shown that DNA …