The tracheal system of insects is a network of epithelial tubules that functions as a
respiratory organ to supply oxygen to various target organs. Target-derived signaling inputs …

The morphology of organs, and hence their proper physiology, relies to a considerable
extent on the extracellular matrix (ECM) secreted by their cells. The ECM is a structure …

A low-frequency variant of sushi, von Willebrand factor type A, EGF, and pentraxin domain-
containing protein 1 (SVEP1), an extracellular matrix protein, is associated with risk of …

Fatty acid (FA) metabolism plays a central role in body homeostasis and related diseases.
Thus, FA metabolic enzymes are attractive targets for drug therapy. Mouse studies on Acetyl …

Membrane expansion integrates multiple forces to mediate precise tube growth and network
formation. Defects lead to deformations, as found in diseases such as polycystic kidney …

Apical extracellular matrix filling the lumen controls the morphology and geometry of
epithelial tubes during development, yet the regulation of luminal protein composition and its …

The morphological stability of biological tubes is crucial for the efficient circulation of fluids
and gases. Failure of this stability causes irregularly shaped tubes found in multiple …

The mechanisms underlying the construction of an air-liquid interface in respiratory organs
remain elusive. Here, we use live imaging and genetic analysis to describe the …

C-type lectins (CTLs) are a large family of Ca 2+-dependent carbohydrate-binding proteins
recognizing various glycoconjugates and functioning primarily in immunity and cell …

Although many organ functions rely on epithelial tubes with correct dimensions,
mechanisms underlying tube size control are poorly understood. We analyse the cellular …