Abstract Estrogen receptor-positive (ER+) breast cancer is the most frequent breast cancer
subtype. Agents targeting the ER signaling pathway have been successful in reducing …

MAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms
that are still poorly understood yet have important clinical implications. Oestrogen-receptor …

Lysine-specific histone demethylase 1 (LSD1), which demethylates mono-or di-methylated
histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development …

Approximately 20% of head and neck squamous cell carcinomas (HNSCCs) exhibit reduced
methylation on lysine 36 of histone H3 (H3K36me) due to mutations in histone methylase …

Acquired resistance to endocrine treatments remains a major clinical challenge. In this
study, we found that desmoglein-2 (DSG2) plays a major role in acquired endocrine …

Molecular-genetic imaging has greatly advanced clinical diagnosis and prognosis
monitoring. However, the specific visualization of intracellular proteins such as estrogen …

Objective to elucidate the correlation between histone demethylase and gastric cancer
Research object histone demethylase and gastric cancer Results As one of the important …

REST corepressors (RCOR s) are the core component of the LSD1/CoREST/HDACs
transcriptional repressor complex, which have been revealed differently expressed in …

In mammals, the histone deacetylase enzymes (HDACs: EC 3.5. 1.98) do catalyze the
cleavage of acetyl-lysine residues on proteins of structural and epigenetic meaning and thus …

Objectives: Prostate cancer holds the second-highest incidence rate among all male
malignancies, with a noticeable scarcity of effective treatment approaches. The REST …