The UDP-glycosyltransferase (UGT) superfamily: new members, new functions, and novel paradigms
UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification
Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
Peroxisome proliferator‐activated receptor alpha target genes
The peroxisome proliferator‐activated receptor alpha (PPARα) is a ligand‐activated
transcription factor involved in the regulation of a variety of processes, ranging from …
transcription factor involved in the regulation of a variety of processes, ranging from …
Peroxisome proliferator-activated receptor α target genes
Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that belong to the
superfamily of nuclear hormone receptors. They mediate the effects of small lipophilic …
superfamily of nuclear hormone receptors. They mediate the effects of small lipophilic …
Liver hypertrophy: a review of adaptive (adverse and non-adverse) changes—conclusions from the 3rd International ESTP Expert Workshop
AP Hall, CR Elcombe, JR Foster… - Toxicologic …, 2012 - journals.sagepub.com
Preclinical toxicity studies have demonstrated that exposure of laboratory animals to liver
enzyme inducers during preclinical safety assessment results in a signature of toxicological …
enzyme inducers during preclinical safety assessment results in a signature of toxicological …
Regulation of drug-metabolizing enzymes and transporters in inflammation
AE Aitken, TA Richardson… - Annu. Rev. Pharmacol …, 2006 - annualreviews.org
▪ Abstract Inflammation and infection have long been known to downregulate the activity and
expression of cytochrome P450 (CYP) enzymes involved in hepatic drug clearance. This …
expression of cytochrome P450 (CYP) enzymes involved in hepatic drug clearance. This …
Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat …
E Hondares, M Rosell, J Díaz-Delfín, Y Olmos… - Journal of Biological …, 2011 - ASBMB
Peroxisome proliferator activated receptor α (PPARα) is a distinctive marker of the brown fat
phenotype that has been proposed to coordinate the transcriptional activation of genes for …
phenotype that has been proposed to coordinate the transcriptional activation of genes for …
PPARs, obesity, and inflammation
The worldwide prevalence of obesity and related metabolic disorders is rising rapidly,
increasing the burden on our healthcare system. Obesity is often accompanied by excess fat …
increasing the burden on our healthcare system. Obesity is often accompanied by excess fat …
Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters
Chemotherapy is one of the three most common treatment modalities for cancer. However,
its efficacy is limited by multidrug resistant cancer cells. Drug metabolizing enzymes (DMEs) …
its efficacy is limited by multidrug resistant cancer cells. Drug metabolizing enzymes (DMEs) …
Green tea extract and (−)‐epigallocatechin‐3‐gallate, the major tea catechin, exert oxidant but lack antioxidant activities
L Elbling, RM Weiss, O Teufelhofer, M Uhl… - The FASEB …, 2005 - Wiley Online Library
Green tea is the most widely consumed beverage. It has attained high reputation as a health‐
promoting dietary component ascribed to the antioxidant activity of (−)‐epigallocatechin‐3 …
promoting dietary component ascribed to the antioxidant activity of (−)‐epigallocatechin‐3 …