Silymarin as supportive treatment in liver diseases: a narrative review

A Gillessen, HHJ Schmidt - Advances in therapy, 2020 - Springer
Silymarin, an extract from milk thistle seeds, has been used for centuries to treat hepatic
conditions. Preclinical data indicate that silymarin can reduce oxidative stress and …

Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases

L Abenavoli, AA Izzo, N Milić, C Cicala… - Phytotherapy …, 2018 - Wiley Online Library
Milk thistle (MT; Silybum marianum), a member of the Asteraceae family, is a therapeutic
herb with a 2,000‐year history of use. MT fruits contain a mixture of flavonolignans …

Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)—Chemistry, Bioavailability, and Metabolism

M Bijak - Molecules, 2017 - mdpi.com
Milk thistle (Silybum marianum) is a medicinal plant that has been used for thousands of
years as a remedy for a variety of ailments. The main component of S. marianum fruit extract …

Formulation strategies for enhancing the bioavailability of silymarin: the state of the art

A Di Costanzo, R Angelico - Molecules, 2019 - mdpi.com
Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable
from milk thistle (Silybum marianum) seeds, has anti-oxidant, anti-inflammatory, anti-cancer …

[HTML][HTML] Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer

M Fallah, A Davoodvandi, S Nikmanzar, S Aghili… - Biomedicine & …, 2021 - Elsevier
Silymarin contains a group of closely-related flavonolignan compounds including silibinin,
and is extracted from Silybum marianum species, also called milk thistle. Silymarin has been …

Role of silymarin in cancer treatment: facts, hypotheses, and questions

T Koltai, L Fliegel - Journal of Evidence-Based Integrative …, 2022 - journals.sagepub.com
The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …

Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality?

CA Houghton, RG Fassett… - Oxidative medicine and …, 2016 - Wiley Online Library
The recognition that food‐derived nonnutrient molecules can modulate gene expression to
influence intracellular molecular mechanisms has seen the emergence of the fields of …

Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin

WL Sun, S Hua, XY Li, L Shen, H Wu, HF Ji - Nature Communications, 2023 - nature.com
Silymarin has been used for improving hepatic damage and lipid disorders, but its action
mechanism remains to be clarified. Here, we investigate the contributions of the gut …

Biosynthesis and cytotoxic effect of silymarin-functionalized selenium nanoparticles induced autophagy mediated cellular apoptosis via downregulation of PI3K/Akt …

X Mi, HS Choi, H Perumalsamy, R Shanmugam… - Phytomedicine, 2022 - Elsevier
Background Silymarin, a blend of flavonolignans isolated from plant Silybum marianum L.,
has long been used as an herbal medicine. Biogenic routes especially the plant-based …

Mechanistic insights into the pharmacological significance of silymarin

K Wadhwa, R Pahwa, M Kumar, S Kumar, PC Sharma… - Molecules, 2022 - mdpi.com
Medicinal plants are considered the reservoir of diverse therapeutic agents and have been
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …