Calcium (Ca2+) and phosphate (PO43−) homeostasis are coordinated by systemic and local
factors that regulate intestinal absorption, influx and efflux from bone, and kidney excretion …

BACKGROUND: Posttranslational modifications (PTMs) greatly expand the function and
regulation of proteins, and glycosylation is the most abundant and diverse PTM. Of the many …

In this special issue of the Glycoconjugate Journal focusing on glycosciences and
development, we summarize recent advances in our understanding of the role of mucin-type …

We used gene array analysis of cortical bone to identify Phex-dependent gene transcripts
associated with abnormal Fgf23 production and mineralization in Hyp mice. We found …

Core-type protein O glycosylation is initiated by polypeptide N-acetylgalactosamine
(GalNAc) transferase (ppGalNAcT) activity and produces the covalent linkage of serine and …

About 250 to 500 glycogenes (genes that are directly involved in glycan metabolism) are in
the human genome representing about 1–2% of the total genome. Over 40 human …

The GALNT3 gene encodes GalNAc‐T3, which prevents degradation of the phosphaturic
hormone, fibroblast growth factor 23 (FGF23). Biallelic mutations in either GALNT3 or FGF23 …

Familial tumoral calcinosis (FTC) refers to a heterogeneous group of inherited disorders
characterized by the occurrence of cutaneous and subcutaneous calcified masses. Two …

Mucin-type O-glycosylation involves the attachment of glycans to an initial O-linked N-
acetylgalactosamine (GalNAc) on serine and threonine residues on proteins. This process in …

Abstract Background Hyperphosphatemic Familial Tumoral Calcinosis (HFTC) and
Hyperphosphatemic Hyperostosis Syndrome (HHS) are associated with autosomal …