CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy
Adoptive cell therapy with chimeric antigen receptor (CAR) immunotherapy has made
tremendous progress with five CAR T therapies approved by the US Food and Drug …
tremendous progress with five CAR T therapies approved by the US Food and Drug …
Navigating CAR-T cells through the solid-tumour microenvironment
AJ Hou, LC Chen, YY Chen - Nature reviews Drug discovery, 2021 - nature.com
The adoptive transfer of T cells that are engineered to express chimeric antigen receptors
(CARs) has shown remarkable success in treating B cell malignancies but only limited …
(CARs) has shown remarkable success in treating B cell malignancies but only limited …
A pragmatic guide to enrichment strategies for mass spectrometry–based glycoproteomics
Glycosylation is a prevalent, yet heterogeneous modification with a broad range of
implications in molecular biology. This heterogeneity precludes enrichment strategies that …
implications in molecular biology. This heterogeneity precludes enrichment strategies that …
Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments
Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target
tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune …
tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune …
Roles of podoplanin in malignant progression of tumor
H Suzuki, MK Kaneko, Y Kato - Cells, 2022 - mdpi.com
Podoplanin (PDPN) is a cell-surface mucin-like glycoprotein that plays a critical role in tumor
development and normal development of the lung, kidney, and lymphatic vascular systems …
development and normal development of the lung, kidney, and lymphatic vascular systems …
The role of O-glycosylation in human disease
O-glycosylation is a highly frequent post-translation modification of proteins, with important
functional implications in both physiological and disease contexts. The biosynthesis of O …
functional implications in both physiological and disease contexts. The biosynthesis of O …
Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy
NJ Bangayan, L Wang, G Burton Sojo… - Proceedings of the …, 2023 - National Acad Sciences
CAR (chimeric antigen receptor) T cell therapy has shown clinical success in treating
hematological malignancies, but its treatment of solid tumors has been limited. One major …
hematological malignancies, but its treatment of solid tumors has been limited. One major …
Tuning the ignition of CAR: optimizing the affinity of scFv to improve CAR-T therapy
Y Duan, R Chen, Y Huang, X Meng, J Chen… - Cellular and Molecular …, 2022 - Springer
How single-chain variable fragments (scFvs) affect the functions of chimeric antigen
receptors (CARs) has not been well studied. Here, the components of CAR with an …
receptors (CARs) has not been well studied. Here, the components of CAR with an …
Targeting overexpressed antigens in glioblastoma via CAR T cells with computationally designed high-affinity protein binders
Z Xia, Q Jin, Z Long, Y He, F Liu, C Sun, J Liao… - Nature Biomedical …, 2024 - nature.com
Chimeric antigen receptor (CAR) T cells targeting receptors on tumour cells have had limited
success in patients with glioblastoma. Here we report the development and therapeutic …
success in patients with glioblastoma. Here we report the development and therapeutic …
Harnessing the power of artificial intelligence to advance cell therapy
S Capponi, KG Daniels - Immunological Reviews, 2023 - Wiley Online Library
Cell therapies are powerful technologies in which human cells are reprogrammed for
therapeutic applications such as killing cancer cells or replacing defective cells. The …
therapeutic applications such as killing cancer cells or replacing defective cells. The …