Gallstone disease is a major health problem that is escalating. To identify risk factors in a
given population, epidemiologic studies must first define the frequency of disease. Such …

Gallstones are common in Western countries and Japan. Most gallstones are found in the
gallbladder, but they sometimes pass through the cystic duct into extrahepatic and/or …

Gallbladder cancer is a relatively rare form of malignancy about which our knowledge is
scant. However, a unique combination of predisposing factors—including genetic …

Triglycerides and cholesterol are important biological lipids, and their excessive intake in the
diet is relevant to the development of two prevalent cardiovascular risk factors, obesity and …

Obesity is a strong risk factor for gallstones. The prevalence of gallstones increases steadily
with increasing body mass index, and gallstones are found in up to 35% of women with a …

Background & Aims: The etiology of cholesterol gallstones is multifactorial, with interactions
of genes and the environment. The hypothesis that aborigine cholesterol lithogenic genes …

Cholelithiasis is one of the most prevalent and most expensive gastroenterologic diseases. It
belongs to the group of complex metabolic disorders that affect humans, and its critical …

Epidemiologic and family studies indicate that cholesterol gallstone formation is in part
genetically determined. The major contribution to our current understanding of gallstone …

Apolipoprotein E (apoE) was discovered as a plasma protein involved in lipoprotein
metabolism. ApoE is synthesized by the liver and is also made locally in the brain. There are …

METHODS AND RESULTS Subjects who had gallstones visible by ultrasound were
considered as cases and subjects negative for gallstones were classified as controls …