For 200 years, the 'closed box'analogy of intracranial pressure (ICP) has underpinned
neurosurgery and neuro-critical care. Cushing conceptualised the Monro-Kellie doctrine …

During exercise: the Kety-Schmidt-determined cerebral blood flow (CBF) does not change
because the jugular vein is collapsed in the upright position. In contrast, when CBF is …

A small decrease in cerebral blood flow (approximately 10%) in response to 100% oxygen
(O2) administration is well recognized. This observation was based on human volunteer …

Oxygenation of cerebral venous outflow has been investigated as a neuromonitor for more
than 50 years (1–3). Currently, jugular venous oxygen saturation (SjVO2) provides an …

Measurement of tissue oxygenation and haemoglobin saturation is of major importance in
the intensive care patient, since conventional monitoring techniques fail to provide …

Metabolic suppression may have a role in cerebral protection. It is often assumed that the
cerebral metabolic and protective effects of qualitative burst suppression are similar to those …

Lactate has been regarded as a waste product of anaerobic metabolism of glucose.
Evidence also suggests, however, that the brain may use lactate as an alternative fuel. Our …

Early detection of neurological deterioration in serious acute brain injury is seen as an
important goal to reduce death and disability, but monitoring for neurological deterioration …

Accurate vascular input function (VIF) derivation is essential in brain dynamic contrast-
enhanced (DCE) MRI. The optimum site for VIF estimation is, however, debated. This study …

Age-related gross head size; adjusted age-related change in brain volume and carotid and
basilar blood flow; as well as scores on 3 tests of fluid intelligence (gf), 2 tests of information …