Current medicinal chemistry strategies in the discovery of novel HIV-1 ribonuclease H inhibitors
L Zhang, F Wei, J Zhang, C Liu… - European Journal of …, 2022 - Elsevier
During HIV-1 genome replication, the viral reverse transcriptase-associated ribonuclease H
(RT-associated RNase H) activity hydrolyzes the RNA strand of RNA/DNA heteroduplex …
(RT-associated RNase H) activity hydrolyzes the RNA strand of RNA/DNA heteroduplex …
Novel Immunoinformatics Approaches to Design Multi-epitope Subunit Vaccine for Malaria by Investigating Anopheles Salivary Protein
Malaria fever has been pervasive for quite a while in tropical developing regions causing
high morbidity and mortality. The causal organism is a protozoan parasite of genus …
high morbidity and mortality. The causal organism is a protozoan parasite of genus …
Immunoinformatics approaches to design a novel multi-epitope subunit vaccine against HIV infection
The end goal of HIV vaccine designing requires novel strategies to elicit a strong humoral
and cell-mediated immune response. The emergence of drug resistance and the …
and cell-mediated immune response. The emergence of drug resistance and the …
Designing B‐and T‐cell multi‐epitope based subunit vaccine using immunoinformatics approach to control Zika virus infection
The Zika virus is a rapidly spreading Aedes mosquito‐borne sickness, which creates an
unanticipated linkage birth deformity and neurological turmoil. This study represents the use …
unanticipated linkage birth deformity and neurological turmoil. This study represents the use …
Excavating chikungunya genome to design B and T cell multi-epitope subunit vaccine using comprehensive immunoinformatics approach to control chikungunya …
Chikungunya infection has been a cause of countless deaths worldwide. Due to lack of
permanent treatment and prevention of this disease, the mortality rate remains very high …
permanent treatment and prevention of this disease, the mortality rate remains very high …
Exploring actinomycetes natural products to identify potential multi-target inhibitors against Leishmania donovani
S Singh, VK Prajapati - 3 Biotech, 2022 - Springer
Visceral leishmaniasis (VL) is a neglected tropical disease that mainly affects the poor
population of the Indian, African, and South American subcontinent. The increasing …
population of the Indian, African, and South American subcontinent. The increasing …
Immunoinformatics design of a novel multi-epitope peptide vaccine to combat multi-drug resistant infections caused by Vibrio vulnificus
Multi-drug resistant Vibrio vulnificus is a Gram-negative bacillus responsible for diseases,
such as: sepsis, septicemia, gastroenteritis, and fatal necrotizing fasciitis in humans. The …
such as: sepsis, septicemia, gastroenteritis, and fatal necrotizing fasciitis in humans. The …
Rational design and Structure− Activity relationship of coumarin derivatives effective on HIV-1 protease and partially on HIV-1 reverse transcriptase
Since dual inhibitors may yield lower toxicity and reduce the likelihood of drug resistance, as
well as inhibitors of HIV-1 PR and RT constitute the core of chemotherapy for AIDS …
well as inhibitors of HIV-1 PR and RT constitute the core of chemotherapy for AIDS …
3D-QSAR, molecular docking and molecular dynamics simulations analyses of a series of heteroaryldihydropyrimidine derivatives as hepatitis B virus capsid …
L Chen, WG Liu, F Xiong, C Ma, C Sun… - New Journal of …, 2021 - pubs.rsc.org
The HBV capsid protein (CP) plays a vital role in the multiple life cycles of HBV and
represents a novel anti-HBV target. Recently, a novel series of heteroaryldihydropyrimidine …
represents a novel anti-HBV target. Recently, a novel series of heteroaryldihydropyrimidine …
Genome-wide screening of vaccine targets prioritization and reverse vaccinology aided design of peptides vaccine to enforce humoral immune response against …
Campylobacter jejuni, gram-negative bacteria, is an infectious agent of foodborne disease-
causing bloody diarrhea, abdominal pain, fever, Guillain-Barré syndrome (GBS) and Miller …
causing bloody diarrhea, abdominal pain, fever, Guillain-Barré syndrome (GBS) and Miller …