Wnts are highly-conserved lipid-modified secreted proteins that activate multiple signaling
pathways. These pathways regulate crucial processes during various stages of development …

Individual cells make decisions that are adapted to their internal state and surroundings, but
how cells can reliably do this remains unclear. To study the information processing capacity …

Planar polarity describes the coordinated polarization of cells within the plane of a tissue.
This is controlled by two main pathways in Drosophila: the Frizzled-dependent core planar …

The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of
the wing and most of the notum of the adult fly. The wing disc first forms during …

Wnt signaling members are involved in the differentiation of cells associated with eyespot
and band color patterns on the wings of butterflies, but the identity and spatio-temporal …

Wings have provided an evolutionary advantage to insects and have allowed them to
diversify. Here, we have identified in Drosophila a highly robust regulatory mechanism that …

The four-pass transmembrane proteins Vangl1 and Vangl2 are dedicated core components
of Wnt/planar cell polarity (Wnt/PCP) signaling that critically regulate polarized cell …

Tissue-wide coordination of polarized cytoskeletal organization and cell behaviour, critical
for normal development, is controlled by asymmetric membrane localization of non …

Intercellular signaling mediated by evolutionarily conserved planar cell polarity (PCP)
proteins aligns cell polarity along the tissue plane and drives polarized cell behaviors during …

Butterfly color patterns provide visible and biodiverse phenotypic readouts of the patterning
processes. Although the secreted ligand WntA has been shown to instruct the color pattern …