[HTML][HTML] Venoms, venomics, antivenomics

JJ Calvete, L Sanz, Y Angulo, B Lomonte, JM Gutiérrez - FEBS letters, 2009 - Elsevier
Venoms comprise mixtures of peptides and proteins tailored by Natural Selection to act on
vital systems of the prey or victim. Here we review our proteomic protocols for uncoiling the …

Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa

DJ Williams, JM Gutiérrez, JJ Calvete, W Wüster… - Journal of …, 2011 - Elsevier
The development of snake antivenoms more than a century ago should have heralded
effective treatment of the scourge of snakebite envenoming in impoverished, mostly rural …

Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability …

JJ Calvete, L Sanz, A Pérez, A Borges, AM Vargas… - Journal of …, 2011 - Elsevier
We describe two geographically differentiated venom phenotypes across the wide
distribution range of Bothrops atrox, from the Colombian Magdalena Medio Valley through …

Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: assessment of geographic variation and its implication on snakebite management

J Boldrini-França, C Corrêa-Netto, MMS Silva… - Journal of …, 2010 - Elsevier
We report the comparative proteomic and antivenomic characterization of the venoms of
subspecies cascavella and collilineatus of the Brazilian tropical rattlesnake Crotalus …

Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of …

V Núñez, P Cid, L Sanz, P De La Torre, Y Angulo… - Journal of …, 2009 - Elsevier
The venom proteomes of Bothrops atrox from Colombia, Brazil, Ecuador, and Perú were
characterized using venomic and antivenomic strategies. Our results evidence the existence …

Scorpions from Mexico: From species diversity to venom complexity

CE Santibáñez-López, OF Francke, C Ureta… - Toxins, 2015 - mdpi.com
Scorpions are among the oldest terrestrial arthropods, which are distributed worldwide,
except for Antarctica and some Pacific islands. Scorpion envenomation represents a public …

Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing

J Durban, P Juárez, Y Angulo, B Lomonte… - BMC genomics, 2011 - Springer
Background A long term research goal of venomics, of applied importance for improving
current antivenom therapy, but also for drug discovery, is to understand the pharmacological …

Nanobody; an old concept and new vehicle for immunotargeting

F Rahbarizadeh, D Ahmadvand… - Immunological …, 2011 - Taylor & Francis
The use of antibodies in cancer therapy has come a long way since the day Paul Ehrlich
described the concept and Kohler and Milstein devised the hybridoma technology to bring …

Recent advances in next generation snakebite antivenoms

C Knudsen, AH Laustsen - Tropical medicine and infectious disease, 2018 - mdpi.com
With the inclusion of snakebite envenoming on the World Health Organization's list of
Neglected Tropical Diseases, an incentive has been established to promote research and …

The molecular basis of venom resistance in a rattlesnake‐squirrel predator‐prey system

HL Gibbs, L Sanz, A Pérez, A Ochoa… - Molecular …, 2020 - Wiley Online Library
Understanding how interspecific interactions mould the molecular basis of adaptations in
coevolving species is a long‐sought goal of evolutionary biology. Venom in predators and …