An update on the discovery and development of reversible covalent inhibitors
Faridoon, R Ng, G Zhang, JJ Li - Medicinal Chemistry Research, 2023 - Springer
Small molecule drugs that covalently bind irreversibly to their target proteins have several
advantages over conventional reversible inhibitors. They include increased duration of …
advantages over conventional reversible inhibitors. They include increased duration of …
Covalent reversible inhibitors of cysteine proteases containing the nitrile warhead: recent advancement in the field of viral and parasitic diseases
S Brogi, R Ibba, S Rossi, S Butini, V Calderone… - Molecules, 2022 - mdpi.com
In the field of drug discovery, the nitrile group is well represented among drugs and
biologically active compounds. It can form both non-covalent and covalent interactions with …
biologically active compounds. It can form both non-covalent and covalent interactions with …
Advances in Cysteine Protease B Inhibitors for Leishmaniasis Treatment
AL Rodriguez Gini, EE João, JR Lopes… - Current Drug …, 2025 - benthamdirect.com
The expression and release of cysteine proteases by Leishmania spp. and their virulence
factors significantly influence the modulation of host immune responses and metabolism …
factors significantly influence the modulation of host immune responses and metabolism …
Planejamento e avaliação de novos derivados 2-iminotiofen-tiazolidínicos como inibidores de cisteína proteases de Trypanosoma cruzi e Leishmania amazonensis
S Júnior, PF da Silva - 2022 - repositorio.ufal.br
RESUMO O termo doenças negligenciadas refere-se a um conjunto de patologias que
acometem cerca de 1 bilhão de indivíduos em todo o mundo, os quais vivem em exclusão …
acometem cerca de 1 bilhão de indivíduos em todo o mundo, os quais vivem em exclusão …
Análise quimiométrica de seletividade nos sítios ativos de cisteíno proteases da família da papaína para o estudo de substâncias antiparasitárias e antineoplásicas
FM Morgantini - 2021 - teses.usp.br
Entre as enzimas pesquisadas pelo Grupo de Química Medicinal e Biológica NEQUIMED
estão as cisteíno proteases (CP), especialmente as envolvidas em doenças negligenciadas …
estão as cisteíno proteases (CP), especialmente as envolvidas em doenças negligenciadas …