The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

In many eukaryotes, including mammals, plants, yeast, and insects, introns can increase
gene expression without functioning as a binding site for transcription factors. This …

One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …

While the human transcriptome contains a large number of circular RNAs (circRNAs), the
functions of most circRNAs remain unclear. Sequence annotation suggests that most …

Background Alternative splicing (AS) is a widespread regulatory mechanism in multicellular
organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS …

An unexpectedly large fraction of genes in metazoans (human, mouse, zebrafish, worm, fruit
fly) express high levels of circularized RNAs containing canonical exons. Here we report that …

Messenger RNA (mRNA) has immense potential for developing a wide range of therapies,
including immunotherapy and protein replacement. As mRNA presents no risk of integration …

Recent improvements in experimental and computational techniques that are used to study
the transcriptome have enabled an unprecedented view of RNA processing, revealing many …

Abstract Background & Aims To clarify the biological roles, circularization process and
secretion pathway of circRHOBTB3 in colorectal cancer (CRC) progression. Methods We …