Transglutaminase regulation of cell function

RL Eckert, MT Kaartinen, M Nurminskaya… - Physiological …, 2014 - journals.physiology.org
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …

Cellular functions of tissue transglutaminase

MV Nurminskaya, AM Belkin - International review of cell and molecular …, 2012 - Elsevier
Transglutaminase 2 (TG2 or tissue transglutaminase) is a highly complex multifunctional
protein that acts as transglutaminase, GTPase/ATPase, protein disulfide isomerase, and …

[HTML][HTML] Transglutaminase 2: a molecular Swiss army knife

S Gundemir, G Colak, J Tucholski… - Biochimica et Biophysica …, 2012 - Elsevier
Transglutaminase 2 (TG2) is the most widely distributed member of the transglutaminase
family with almost all cell types in the body expressing TG2 to varying extents. In addition to …

Tissue transglutaminase: A multifunctional and multisite regulator in health and disease

Z Yao, Y Fan, L Lin, RE Kellems… - Physiological …, 2024 - journals.physiology.org
Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

A novel function of tissue-type transglutaminase: protein disulphide isomerase

G Hasegawa, M Suwa, Y Ichikawa… - Biochemical …, 2003 - portlandpress.com
We have found that tissue-type transglutaminase (tTG), also called TGc, TGase2 and Gαh,
has the activity of protein disulphide isomerase (PDI). We have shown that tTG converts …

Transglutaminase 2 induces nuclear factor-κB activation via a novel pathway in BV-2 microglia

J Lee, YS Kim, DH Choi, MS Bang, TR Han… - Journal of Biological …, 2004 - ASBMB
Transglutaminase 2 (TGase 2) expression is increased in inflammatory diseases. We
demonstrated previously that inhibitors of TGase 2 reduce nitric oxide (NO) generation in a …

Differential expression of multiple transglutaminases in human brain: increased expression and cross-linking by transglutaminases 1 and 2 in Alzheimer's disease

SY Kim, P Grant, JH Lee, HC Pant… - Journal of Biological …, 1999 - ASBMB
The transglutaminase (TGase) family of enzymes, of which seven different members are
known in the human genome, participate in many biological processes involving cross …

Transglutaminase 2: a multi-functional protein in multiple subcellular compartments

D Park, SS Choi, KS Ha - Amino acids, 2010 - Springer
Abstract Transglutaminase 2 (TG2) is a multifunctional protein that can function as a
transglutaminase, G protein, kinase, protein disulfide isomerase, and as an adaptor protein …

Tissue transglutaminase: a possible role in neurodegenerative diseases

M Lesort, J Tucholski, ML Miller, GVW Johnson - Progress in neurobiology, 2000 - Elsevier
Tissue transglutaminase is a multifunctional protein that is likely to play a role in numerous
processes in the nervous system. Tissue transglutaminase posttranslationally modifies …

Protein crosslinking, tissue transglutaminase, alternative splicing and neurodegeneration

BA Citron, Z Suo, K SantaCruz, PJA Davies… - Neurochemistry …, 2002 - Elsevier
Increasing interest and awareness of protein aggregation as being implicated in
neurodegenerative processes has developed in recent years. One novel mechanism for this …