Do long noncoding RNAs (lncRNAs) contribute little or substantively to human biology? To
address how lncRNA loci and their transcripts, structures, interactions, and functions …

Abstract The International Mouse Phenotyping Consortium (IMPC; https://www.
mousephenotype. org/) web portal makes available curated, integrated and analysed …

Pleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis
(whereby non-linear interactions between genetic polymorphisms affect the same trait) are …

Bivalent genes are ready for activation upon the arrival of developmental cues. Here, we
report that BEND3 is a CpG island (CGI)–binding protein that is enriched at regulatory …

Abstract Interleukin-17A (IL-17A) is a key mediator of protective immunity to yeast and
bacterial infections but also drives the pathogenesis of several autoimmune diseases, such …

Platelet homeostasis is essential for vascular integrity and immune defence,. Although the
process of platelet formation by fragmenting megakaryocytes (MKs; thrombopoiesis) has …

Genomic instability arising from defective responses to DNA damage or mitotic
chromosomal imbalances can lead to the sequestration of DNA in aberrant extranuclear …

Auxin-inducible degrons are a chemical genetic tool for targeted protein degradation and
are widely used to study protein function in cultured mammalian cells. Here, we develop …

Precision medicine strives for highly individualized treatments for disease under the notion
that each individual's unique genetic makeup and environmental exposures imprints upon …

The starting point in a mutational analysis of gene function is obtaining or producing a
mutant. Here different methods of obtaining mouse mutants are discussed, including …