The traditional description of cardiac development involves progression from a cardiac
crescent to a linear heart tube, which in the phase of transformation into a mature heart …

Background Studies have suggested that many down-regulated miRNAs identified in the
brain tissue or serum of Alzheimer's disease (AD) patients were involved in the formation of …

Human induced pluripotent stem cells (hiPSCs) can be used to generate various cell types
in the human body. Hence, hiPSC-derived cardiomyocytes (hiPSC-CMs) represent a …

Noncoding RNAs (ncRNAs) play fundamental roles in cardiac development and
cardiovascular diseases (CVDs), which are a major cause of morbidity and mortality. With …

Cardiac development is a complex and intricate process involving numerous molecular
signals and pathways. Researchers have explored cardiac development through a long …

Cardiovascular diseases (CVD) are a group of disorders that affect the heart and blood
vessels. They include conditions such as myocardial infarction, coronary artery disease …

The embryonic epicardium originates from the proepicardium, an extracardiac primordium
constituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is …

Myocardial cell fate specification takes place during the early stages of heart development
as the precardiac mesoderm is configured into two symmetrical sets of bilateral precursor …

Abstract Background Cardiomyocytes (CMs) derived from human induced pluripotent stem
cells (hiPSCs) by traditional methods are a mix of atrial and ventricular CMs and many other …

A large diversity of epigenetic factors, such as microRNAs and histones modifications, are
known to be capable of regulating gene expression without altering DNA sequence itself. In …