Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia
S Beneyto-Calabuig, AK Merbach, JA Kniffka, M Antes… - Cell Stem Cell, 2023 - cell.com
Inter-patient variability and the similarity of healthy and leukemic stem cells (LSCs) have
impeded the characterization of LSCs in acute myeloid leukemia (AML) and their …
impeded the characterization of LSCs in acute myeloid leukemia (AML) and their …
Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity
TBK Watkins, EC Colliver, MR Huska… - PLoS computational …, 2023 - journals.plos.org
Most computational methods that infer somatic copy number alterations (SCNAs) from bulk
sequencing of DNA analyse tumour samples individually. However, the sequencing of …
sequencing of DNA analyse tumour samples individually. However, the sequencing of …
HATCHet2: clone-and haplotype-specific copy number inference from bulk tumor sequencing data
Bulk DNA sequencing of multiple samples from the same tumor is becoming common, yet
most methods to infer copy-number aberrations (CNAs) from this data analyze individual …
most methods to infer copy-number aberrations (CNAs) from this data analyze individual …
Refphase: Multi-sample reference phasing reveals haplotype-specific copy number heterogeneity
Most computational methods that infer somatic copy number alterations (SCNAs) from bulk
sequencing of DNA analyse tumour samples individually. However, the sequencing of …
sequencing of DNA analyse tumour samples individually. However, the sequencing of …
Bayesian inference for copy number intra-tumoral heterogeneity from single-cell RNA-sequencing data
PX Qiao, CF Kwok, G Qian, DJ McCarthy - bioRxiv, 2023 - biorxiv.org
High-resolution molecular characterization of intra-tumoral clonal structure defined by
genomic and epigenomic alterations is crucial in understanding the natural history of tumors …
genomic and epigenomic alterations is crucial in understanding the natural history of tumors …
[图书][B] Inferring Intra-Tumor Heterogeneity from DNA Sequencing Data
MA Myers - 2022 - search.proquest.com
Cancer is a disease characterized by somatic mutations which accumulate over time and in
response to evolutionary pressures. As a result, tumors are composed of multiple distinct …
response to evolutionary pressures. As a result, tumors are composed of multiple distinct …