Cell-penetrating peptides (CPPs) as therapeutic and diagnostic agents for cancer

RA Bottens, T Yamada - Cancers, 2022 - mdpi.com
Simple Summary Crossing biological barriers is often required for drug delivery. Cell-
penetrating peptides (CPPs) are short strands of amino acids that have been widely used as …

Nano drug delivery systems: a mini-review

VN Syam Kumar, S Sunkar… - Nanoscience & …, 2023 - ingentaconnect.com
Medical nanotechnology is surfacing as a challenging arena covering new biomedical
applications, such as drug delivery, treatment, nano diagnosis, controlled drug release …

Ketone bodies induce unique inhibition of tumor cell proliferation and enhance the efficacy of anti-cancer agents

AI Miller, D Diaz, B Lin, PK Krzesaj, S Ustoyev, A Shim… - Biomedicines, 2023 - mdpi.com
The ketone bodies, sodium and lithium salts of acetoacetate (AcAc) and sodium 3-
hydroxybutyrate (3-HB; commonly called beta-hydroxybutyrate) have been found to inhibit …

Cell Membrane Perforation: Patterns, Mechanisms and Functions

X Zhu, Z Shi, Y Mao, U Lächelt, R Huang - Small, 2024 - Wiley Online Library
Cell membrane is crucial for the cellular activities, and any disruption to it may affect the
cells. It is demonstrated that cell membrane perforation is associated with some biological …

Phage libraries screening on P53: Yield improvement by zinc and a new parasites-integrating analysis

S Ben Abid, E Ketata, I Yacoubi, L Djemal… - PloS one, 2024 - journals.plos.org
P53 is a transcription factor that controls a variety of genes, primarily involved in cell cycle
and other processes related to cell survival and death. We have isolated peptides targeting …

Peptides that block RAS-p21 protein-induced cell transformation

MR Pincus, B Lin, P Patel, E Gabutan, N Zohar… - Biomedicines, 2023 - mdpi.com
This is a review of approaches to the design of peptides and small molecules that selectively
block the oncogenic RAS-p21 protein in ras-induced cancers. Single amino acid …

Anti-Cancer Peptide PNC-27 Kills Cancer Cells by Unique Interactions with Plasma Membrane-Bound hdm-2 and with Mitochondrial Membranes Causing …

P Krzesaj, V Adler, RD Feinman… - Annals of Clinical & …, 2024 - Assoc Clin Scientists
Objective We have previously shown that the anti-cancer peptide PNC-27 kills cancer cells
by co-localizing with membrane-expressed HDM-2, resulting in transmembrane pore …

Recent advances and applications of peptide–agent conjugates for targeting tumor cells

V Alamdari-Palangi, KR Jaberi, M Shahverdi… - Journal of Cancer …, 2023 - Springer
Background Cancer, being a complex disease, presents a major challenge for the scientific
and medical communities. Peptide therapeutics have played a significant role in different …

Poptosis or Peptide-Induced Transmembrane Pore Formation: A Novel Way to Kill Cancer Cells without Affecting Normal Cells

MR Pincus, M Silberstein, N Zohar, E Sarafraz-Yazdi… - Biomedicines, 2024 - mdpi.com
Recent advances in cancer treatment like personalized chemotherapy and immunotherapy
are aimed at tumors that meet certain specifications. In this review, we describe a new …

Phage libraries screening on P53: yield improvement by zinc and a new parasites integrating analysis and rationale

S Ben Abid, E Ketata, I Yacoubi-Hadj Amor… - bioRxiv, 2023 - biorxiv.org
P53 is a transcription factor that controls a variety of genes, primarily involved in cell cycle
and other processes related to cell survival and death. We have isolated peptides targeting …