Various physiological processes involve appropriate tissue developmental process and
homeostasis-the pathogenesis of several diseases connected with deregulatory apoptosis …

Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery
more than two decades ago, the use of survivin as a target for cancer therapeutics has …

A new coronavirus (SARS-CoV-2) has been identified as the etiologic agent for the COVID-
19 outbreak. Currently, effective treatment options remain very limited for this disease; …

Underneath the intricacy of every cancer lies mysterious events that impel the tumour cell
and its posterity into abnormal growth and tissue invasion. Oncogenic mutations disturb the …

Data on gastroenteropancreatic neuroendocrine neoplasms (NEN) G3 (well-differentiated
neuroendocrine tumors (NET G3) and neuroendocrine carcinoma (NEC)) are limited. We …

Background Neuroblastoma is the most common solid tumor in infants accounting for
approximately 15% of all cancer-related deaths. Over 50% of high-risk neuroblastoma …

With almost 4000 citations in Medline in a little over 10years, survivin has certainly kept
scores of investigators busy worldwide. Tangible progress has been made in revealing the …

Apoptosis, a physiological process of programmed cell death, is disrupted in various
malignancies. It has been exploited as an anti-cancer strategy traditionally by inducing DNA …

Since the discovery of survivin (BIRC5) as a cancer-related molecule by Grazia Ambrosini
and Dario C. Altieri at 1997, our knowledge related to the function of this molecule has been …

Abstract Background This phase I/II study examined the safety and efficacy of Sepantronium
Bromide (S), a small-molecule selective survivin suppressant, administered in combination …