Several lines of evidence suggest that proliferation and differentiation in neural stem cells
(NSCs) are a major convergence point of neurodevelopmental disorders (NDDs). Most …

Background CHD8 (chromodomain helicase DNA-binding protein 8), which codes for a
member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the …

The multi‐subunit eEF1 complex plays a crucial role in de novo protein synthesis. The
central functional component of the complex is eEF1A, which occurs as two independently …

The Neanderthal and Denisovan genomes enabled the discovery of sequences that differ
between modern and archaic humans, the majority of which are noncoding. However, our …

Fragile X syndrome (FXS) is caused by a repression of the FMR1 gene that codes the
Fragile X mental retardation protein (FMRP), an RNA binding protein involved in processes …

Bisphenol A (BPA) is a ubiquitous environmental chemical that has been linked to
behavioral differences in children and shown to impact critical neurodevelopmental …

Autism spectrum disorder (ASD) is highly heritable but genetically heterogeneous. The
affected neural circuits and cell types remain unclear and may vary at different …

Abstract Background Phelan-McDermid syndrome (PMS) is a rare genetic disorder with high
risk of autism spectrum disorder (ASD), intellectual disability, and language delay, and is …

Highlights•Dysregulation of embryonic and adult neurogenesis may be linked to
neuropsychiatric disorders.•Mutations in functionally distinct NPD-genes affect neural stem …

Mutations in chromodomain helicase DNA‐binding domain 8 (CHD8) have been identified
in independent genotyping studies of autism spectrum disorder. To better understand the …