Amino acids are necessary for all living cells and organisms. Specialized transporters
mediate the transfer of amino acids across plasma membranes. Malfunction of these …

The transport of amino acids in kidney and intestine is critical for the supply of amino acids to
all tissues and the homeostasis of plasma amino acid levels. This is illustrated by a number …

Pulmonary alveolar proteinosis is a rare clinical syndrome that was first described in 1958.
Subsequently, over 240 case reports and small series have described at least 410 cases in …

The SLC7 family is divided into two subgroups, the cationic amino acid transporters (the
CAT family, SLC7A1–4) and the glycoprotein-associated amino acid transporters (the gpaAT …

The small intestine mediates the absorption of amino acids after ingestion of protein and
sustains the supply of amino acids to all tissues. The small intestine is an important …

The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids
across the membrane and is crucial for brain drug delivery and tumor growth. LAT1 forms a …

Although it was originally believed that thyroid hormones enter target cells by passive
diffusion, it is now clear that cellular uptake is effected by carrier-mediated processes. Two …

Finland, located at the edge of the inhabitable world, is one of the best-studied genetic
isolates. The characteristic features of population isolates—founder effect, genetic drift and …

We have identified a new human cDNA, L-amino acid transporter-2 (LAT-2), that induces a
system L transport activity with 4F2hc (the heavy chain of the surface antigen 4F2, also …

Amino acid, polyamine, and organocation (APC) transporters are secondary transporters
that play essential roles in nutrient uptake, neurotransmitter recycling, ionic homeostasis …