The borders between cell and developmental biology, which have always been permeable,
have largely dissolved. One manifestation is the blossoming of cilia biology, with cell and …

The primary cilium is a ubiquitous microtubule-based organelle that senses external
environment and modulates diverse signaling pathways in different cell types and tissues …

The first steps of vision take place in the ciliary outer segment compartment of photoreceptor
cells. The protein composition of outer segments is uniquely suited to perform this function …

The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified
cilium filled with hundreds of flattened 'disc'membranes that provide vast light-absorbing …

Cilia sense and transduce sensory stimuli, homeostatic cues and developmental signals by
orchestrating signaling reactions. Extracellular vesicles (EVs) that bud from the ciliary …

As signalling organelles, cilia regulate their G protein-coupled receptor content by
ectocytosis, a process requiring localised actin dynamics to alter membrane shape …

The outer segments (OS) of rod and cone photoreceptor cells are specialized sensory cilia
that contain hundreds of opsin-loaded stacked membrane disks that enable …

The rod and cone photoreceptor cells of the vertebrate retina have highly specialized
structures that enable them to carry out their function of light detection over a broad range of …

The photoreceptor outer segment is a modified cilium filled with hundreds of flattened “disc”
membranes responsible for efficient light capture. To maintain photoreceptor health and …

Functional compartmentalization of cells is a universal strategy for segregating processes
that require specific components, undergo regulation by modulating concentrations of those …