Naive T cells have long been regarded as a developmentally synchronized and fairly
homogeneous and quiescent cell population, the size of which depends on age, thymic …

The decline of the immune system appears to be an intractable consequence of aging,
leading to increased susceptibility to infections, reduced effectiveness of vaccination and …

Virus-specific CD8+ T-cell responses play a pivotal role in limiting viral replication.
Alterations in these responses, such as decreased cytolytic function, inappropriate …

Human CD8+ memory-and effector-type T cells are poorly defined. We show here that, next
to a naive compartment, two discrete primed subpopulations can be found within the …

Highly active antiretroviral therapy (HAART) increases CD4+ cell numbers, but its ability to
correct the human immunodeficiency virus (HIV)–induced immune deficiency remains …

Over 850 Leishmania-human immunodeficiency virus (HIV) coinfection cases have been
recorded, the majority in Europe, where 7 to 17% of HIV-positive individuals with fever have …

This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

Parenteral administration of a mouse anti-human CD8 monoclonal antibody (MAb) to rhesus
macaques resulted in a transient depletion of CD8+ cells in both the peripheral blood and …

Ageing is associated with complex remodelling in the phenotypic and functional profiles of T
lymphocytes. We investigated whether expression of CD28 antigen on T cells is conserved …

The dramatic decline in immune function with age, especially in T cell proliferative activity,
has been documented extensively in experimental animal models and in clinical studies of …