The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
exert essential regulatory function in microbial-and onco-immunology through the induction …

With aging, the incidence of age-related diseases increases. Hence, age-related diseases
are inevitable. However, the mechanisms by which aging leads to the onset and progression …

Abstract Introduction Meteorin-like hormone (Metrnl) is ubiquitously expressed in skeletal
muscle, heart, and adipose with beneficial roles in obesity, insulin resistance, and …

Macrophage plasticity is critical for normal tissue repair following injury. In pathologic states
such as diabetes, macrophage plasticity is impaired, and macrophages remain in a …

Defective mitophagy is causally linked to obesity complications. Here, we identified an
interaction between mitophagy protein FUNDC1 (FUN14 domain containing 1) and receptor …

In the classic Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP)
synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can …

Mitochondrial dysfunction may play a crucial role in various diseases due to its roles in the
regulation of energy production and cellular metabolism. Serine/threonine kinase (AKT) is a …

The endoplasmic reticulum (ER) hosts linear polypeptides and fosters natural folding of
proteins through ER-residing chaperones and enzymes. Failure of the ER to align and …

The innate immune system protects the host from external pathogens and internal damage
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …

Chronic kidney disease (CKD) is well recognized as a distinct contributor to cardiac
hypertrophy, while the underlying mechanism remains incompletely understood. Here, the …