Clinical proton MR spectroscopy in central nervous system disorders

G Öz, JR Alger, PB Barker, R Bartha, A Bizzi, C Boesch… - Radiology, 2014 - pubs.rsna.org
A large body of published work shows that proton (hydrogen 1 [1H]) magnetic resonance
(MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality …

MR spectroscopic imaging: principles and recent advances

S Posse, R Otazo, SR Dager… - Journal of Magnetic …, 2013 - Wiley Online Library
MR spectroscopic imaging (MRSI) has become a valuable tool for quantifying metabolic
abnormalities in human brain, prostate, breast and other organs. It is used in routine clinical …

Contribution of macromolecules to brain 1H MR spectra: Experts' consensus recommendations

C Cudalbu, KL Behar, PK Bhattacharyya… - NMR in …, 2021 - Wiley Online Library
Proton MR spectra of the brain, especially those measured at short and intermediate echo
times, contain signals from mobile macromolecules (MM). A description of the main MM is …

In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4T vs. 7T

I Tkáč, G Öz, G Adriany, K Uğurbil… - Magnetic Resonance in …, 2009 - Wiley Online Library
A comprehensive comparative study of metabolite quantification from the human brain was
performed on the same 10 subjects at 4T and 7T using MR scanners with identical consoles …

Accelerated MR spectroscopic imaging—a review of current and emerging techniques

W Bogner, R Otazo, A Henning - NMR in Biomedicine, 2021 - Wiley Online Library
Over more than 30 years in vivo MR spectroscopic imaging (MRSI) has undergone an
enormous evolution from theoretical concepts in the early 1980s to the robust imaging …

Proton and multinuclear magnetic resonance spectroscopy in the human brain at ultra-high field strength: A review

A Henning - Neuroimage, 2018 - Elsevier
Abstract Magnetic Resonance Spectroscopy (MRS) allows for a non-invasive and non-
ionizing determination of in vivo tissue concentrations and metabolic turn-over rates of more …

Slice‐selective FID acquisition, localized by outer volume suppression (FIDLOVS) for 1H‐MRSI of the human brain at 7 T with minimal signal loss

A Henning, A Fuchs, JB Murdoch… - NMR in Biomedicine …, 2009 - Wiley Online Library
Abstract In comparison to 1.5 and 3 T, MR spectroscopic imaging at 7 T benefits from signal‐
to‐noise ratio (SNR) gain and increased spectral resolution and should enable mapping of a …

[HTML][HTML] Ultra-high resolution brain metabolite mapping at 7 T by short-TR Hadamard-encoded FID-MRSI

G Hangel, B Strasser, M Považan, E Heckova… - Neuroimage, 2018 - Elsevier
MRSI in the brain at≥ 7 T is a technique of great promise, but has been limited mainly by
low B 0/B 1+-homogeneity, specific absorption rate restrictions, long measurement times …

Proton echo‐planar spectroscopic imaging of J‐coupled resonances in human brain at 3 and 4 Tesla

S Posse, R Otazo, A Caprihan, J Bustillo… - … in Medicine: An …, 2007 - Wiley Online Library
In this multicenter study, 2D spatial mapping of J‐coupled resonances at 3T and 4T was
performed using short‐TE (15 ms) proton echo‐planar spectroscopic imaging (PEPSI) …

MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosis

R Srinivasan, H Ratiney… - Magnetic resonance …, 2010 - Elsevier
Detection of glutathione (GSH) is technically challenging at clinical field strengths of 1.5 or 3
T due to its low concentration in the human brain coupled with the fact that conventional …