The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances

P Saraei, I Asadi, MA Kakar… - Cancer management and …, 2019 - Taylor & Francis
Metformin is a widely used drug in today's prescriptions by physicians due to its specific
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …

Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: a systematic review and meta-analysis

JM Campbell, SM Bellman, MD Stephenson… - Ageing Research …, 2017 - Elsevier
This systematic review investigated whether the insulin sensitiser metformin has a
geroprotective effect in humans. Pubmed and Embase were searched along with databases …

Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders

S Gandini, M Puntoni, BM Heckman-Stoddard… - Cancer prevention …, 2014 - AACR
Previous meta-analyses have shown that the antidiabetic agent metformin is associated with
reduced cancer incidence and mortality. However, this effect has not been consistently …

Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review

M Franciosi, G Lucisano, E Lapice, GFM Strippoli… - PloS one, 2013 - journals.plos.org
Aims/Hypothesis Diabetes treatments were related with either an increased or reduced risk
of cancer. There is ongoing debate about a potential protective action of metformin. To …

Association of metformin use with cancer incidence and mortality: a meta-analysis

P Zhang, H Li, X Tan, L Chen, S Wang - Cancer epidemiology, 2013 - Elsevier
PURPOSE: To assess the effect of metformin intake on cancer incidence and mortality.
METHODS: Original articles in English published until June 15, 2012 were searched for in …

Metformin and cancer: new applications for an old drug

TV Kourelis, RD Siegel - Medical Oncology, 2012 - Springer
Metformin, one of most widely prescribed oral hypoglycemic agents, has recently received
increased attention because of its potential antitumorigenic effects that are thought to be …

Metformin inhibits melanoma cell metastasis by suppressing the miR-5100/SPINK5/STAT3 axis

D Suwei, X Yanbin, W Jianqiang, M Xiang… - Cellular & Molecular …, 2022 - Springer
Melanoma is the most lethal skin cancer characterized by its high metastatic potential. It is
urgent to find novel therapy strategies to overcome this feature. Metformin has been …

Diabetes in older people

GS Meneilly, A Knip, DB Miller, D Sherifali… - Canadian journal of …, 2018 - Elsevier
This guideline refers primarily to type 2 diabetes in the older person. There is limited
information on the management of type 1 diabetes in the elderly, but this is included …

From obesity to diabetes and cancer: epidemiological links and role of therapies

C García-Jiménez, M Gutiérrez-Salmerón… - British journal of …, 2016 - nature.com
Increasing evidence suggests a complex relationship between obesity, diabetes and cancer.
Here we review the evidence for the association between obesity and diabetes and a wide …

Metformin is associated with reduced risk of pancreatic cancer in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Z Wang, S Lai, L Xie, J Zhao, N Ma, J Zhu, Z Ren… - Diabetes research and …, 2014 - Elsevier
Aims Recent epidemiological studies indicated that use of metformin might decrease the risk
of various cancers among patients with type 2 diabetes mellitus (T2DM). However, its …