The ability of tumor cells to adapt to changes in oxygen tension is essential for tumor
development. Low oxygen concentration influences cellular metabolism and, thus, affects …

Breast cancer is the most commonly diagnosed and the most lethal cancer in females both
in China and worldwide. Currently, the origin of cancer stem cells, the heterogeneity of …

Tumor cells are dominant in the nutritional competition in the tumor microenvironment, and
their metabolic abnormalities often lead to microenvironmental acidosis and nutrient …

Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and
metastasis. A developmental programme known as epithelial-to-mesenchymal transition …

Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent
carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid …

The key proteins involved in transcriptional regulation play convergent roles in cellular
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …

Cancer cell proliferation in some organs often depends on conversion of pyruvate to
oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to …

The poor prognosis of serous ovarian cancer (SOC) is due to its high invasive capacity and
cisplatin resistance of SOC cells, whereas the molecular mechanisms remain poorly …

Background 13C tracer analysis is increasingly used to monitor cellular metabolism in vivo
and in intact cells, but data interpretation is still the key element to unveil the complexity of …

Osteosarcoma is one of the most common malignant bone tumors. However, the treatment
and clinical outcomes of osteosarcoma have hardly changed over the past three decades …