Natural history of metabolic dysfunction-associated steatotic liver disease

V Lekakis, GV Papatheodoridis - European Journal of Internal Medicine, 2024 - Elsevier
Metabolic dysfunction-associated steatotic liver disease (MASLD), which has been the term
for non-alcoholic fatty liver disease (NAFLD) since June 2023, represents the most common …

Natural history and progression of metabolic dysfunction-associated steatotic liver disease

H Hagström, Y Shang, H Hegmar… - … Lancet Gastroenterology & …, 2024 - thelancet.com
The natural history of metabolic dysfunction-associated steatotic liver disease (MASLD),
previously referred to as non-alcoholic fatty liver disease (NAFLD), is complex and long. A …

Non-invasive biomarkers for liver inflammation in non-alcoholic fatty liver disease: present and future

TCF Yip, F Lyu, H Lin, G Li, PC Yuen… - Clinical and …, 2022 - pmc.ncbi.nlm.nih.gov
Inflammation is the key driver of liver fibrosis progression in non-alcoholic fatty liver disease
(NAFLD). Unfortunately, it is often challenging to assess inflammation in NAFLD due to its …

Endpoints in NASH clinical trials: are we blind in one eye?

A Lonardo, S Ballestri, A Mantovani, G Targher, F Bril - Metabolites, 2024 - mdpi.com
This narrative review aims to illustrate the notion that nonalcoholic steatohepatitis (NASH),
recently renamed metabolic dysfunction-associated steatohepatitis (MASH), is a systemic …

[HTML][HTML] A novel experimental mouse model of diabetic nonalcoholic steatohepatitis: A critical role for acid-sensitive Ion Channel 1a

X Hu, H Lin, S Qian, Z Xu, Z Li, S Qian, F Yang… - Biomedicine & …, 2024 - Elsevier
Background A two-way relationship exists between type 2 diabetes (T2DM) and human
nonalcoholic steatohepatitis (NASH). Several diabetic NASH models have the …

Spatial lipidomics reveals zone-specific hepatic lipid alteration and remodeling in metabolic dysfunction-associated steatohepatitis

P Seubnooch, M Montani, JF Dufour, M Masoodi - Journal of lipid research, 2024 - jlr.org
Alteration in lipid metabolism plays a pivotal role in developing metabolic dysfunction-
associated steatohepatitis (MASH). However, our understanding of alteration in lipid …

Glycated haemoglobin is a major predictor of disease severity in patients with NAFLD

S Colosimo, H Miller, DA Koutoukidis, T Marjot… - Diabetes research and …, 2024 - Elsevier
Objectives Currently, non-invasive scoring systems to stage the severity of non-alcoholic
fatty liver disease (NAFLD) do not consider markers of glucose control (glycated …

Metabolic-associated fatty liver disease and the role of hormones in its aetiopathogenesis

S Suwała, R Junik - Endokrynologia Polska, 2024 - journals.viamedica.pl
Metaboli ca ssociated fatty liver disease (MAFLD) is a newly coined term that links the
presence of liver steatosis (characterised by the accumulation of lipids in at least 5% of liver …

FIB-4 is closer to FibroScan screen results to detecting advanced liver fibrosis and maybe facilitates NAFLD warning

Y Ding, Z Wang, H Niu, Q Deng, Y Wang, S Xia - Medicine, 2023 - journals.lww.com
To assess the relationship between clinical biochemical characteristics and steatosis or
fibrosis by Fibroscan in non-alcoholic fatty liver disease (NAFLD) patients in order to seek …

Estimated Burden of Metabolic Dysfunction–Associated Steatotic Liver Disease in US Adults, 2020 to 2050

P Le, M Tatar, S Dasarathy, N Alkhouri… - JAMA Network …, 2025 - jamanetwork.com
Importance Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most
common cause of chronic liver disease and is projected to become the leading indication for …