Microglia in neuroinflammation and neurodegeneration: from understanding to therapy

L Muzio, A Viotti, G Martino - Frontiers in neuroscience, 2021 - frontiersin.org
Microglia are the resident macrophages of the central nervous system (CNS) acting as the
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

A Ciesielska, M Matyjek, K Kwiatkowska - Cellular and molecular life …, 2021 - Springer
Abstract Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-
inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide …

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

T Guo, D Zhang, Y Zeng, TY Huang, H Xu… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

[HTML][HTML] Brain-gut-microbiota axis in Alzheimer's disease

K Kowalski, A Mulak - Journal of neurogastroenterology and …, 2019 - ncbi.nlm.nih.gov
Disturbances along the brain-gut-microbiota axis may significantly contribute to the
pathogenesis of neurodegenerative disorders. Alzheimer's disease (AD) is the most frequent …

The microbiota–gut–brain axis and Alzheimer's disease: neuroinflammation is to blame?

A Megur, D Baltriukienė, V Bukelskienė, A Burokas - Nutrients, 2020 - mdpi.com
For years, it has been reported that Alzheimer's disease (AD) is the most common cause of
dementia. Various external and internal factors may contribute to the early onset of AD. This …

Immune attack: the role of inflammation in Alzheimer disease

FL Heppner, RM Ransohoff, B Becher - Nature Reviews Neuroscience, 2015 - nature.com
The past two decades of research into the pathogenesis of Alzheimer disease (AD) have
been driven largely by the amyloid hypothesis; the neuroinflammation that is associated with …

Inflammatory response in the CNS: friend or foe?

M Sochocka, BS Diniz, J Leszek - Molecular neurobiology, 2017 - Springer
Inflammatory reactions could be both beneficial and detrimental to the brain, depending on
strengths of their activation in various stages of neurodegeneration. Mild activation of …

Lipopolysaccharide associates with amyloid plaques, neurons and oligodendrocytes in Alzheimer's disease brain: a review

X Zhan, B Stamova, FR Sharp - Frontiers in aging neuroscience, 2018 - frontiersin.org
This review proposes that lipopolysaccharide (LPS, found in the wall of all Gram-negative
bacteria) could play a role in causing sporadic Alzheimer's disease (AD). This is based in …

Physiology of microglia

H Kettenmann, UK Hanisch, M Noda… - Physiological …, 2011 - journals.physiology.org
Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside

A Mishra, R Bandopadhyay, PK Singh, PS Mishra… - Metabolic Brain …, 2021 - Springer
Neuroinflammation is one of the host defensive mechanisms through which the nervous
system protects itself from pathogenic and or infectious insults. Moreover, neuroinflammation …