Primary graft dysfunction (PGD) is the clinical syndrome of acute lung injury after lung
transplantation (LTx). However, PGD is an umbrella term that encompasses the ongoing …

Lung transplantation is often the only viable treatment option for a patient with end-stage
lung disease. Lung transplant results have improved substantially over time, but ischemia …

Rationale: Primary graft dysfunction (PGD) is a severe form of acute lung injury, leading to
increased early morbidity and mortality after lung transplant. Obesity is a major health …

Ex vivo lung perfusion (EVLP) is an excellent platform to apply novel therapeutics, such as
gene and cell therapies, before lung transplantation. We investigated the concept of human …

Background Lung ischemia reperfusion injury (IRI) is the principal cause of primary graft
dysfunction (PGD) after lung transplantation, affecting short-term and long-term mortality …

OBJECTIVE: Ischemia-reperfusion (IR) is the main cause of acute lung injury (ALI) in clinical
lung transplantation, extracorporeal circulation, lung sleeve resection, trauma and …

The use of extracorporeal life support (ECLS) throughout the perioperative phase of lung
transplantation requires nuanced planning and execution by an integrated team of …

Introduction Primary graft dysfunction (PGD) is a known risk factor for early mortality
following lung transplant (LT). However, the outcomes of patients who achieve long-term …

Mesenchymal Stem Cells (MSCs) are being investigated as a treatment for a novel viral
disease owing to their immunomodulatory, anti-inflammatory, tissue repair and regeneration …

The success of lung transplantation is limited by the high rate of primary graft dysfunction
due to ischemia-reperfusion injury (IRI). Lung IRI is characterized by a robust inflammatory …