Cardiac arrest causes devastating neurologic morbidity and mortality. The preservation of
the brain function is the final goal of resuscitation. Therapeutic hypothermia (TH) has been …

Acute ischemic stroke is a leading cause of death and disability worldwide. Therapeutic
hypothermia has long been considered as one of the most robust neuroprotective strategies …

This is a prospective non-randomized cohort study of 113 consecutive patients to investigate
the safety and efficacy of a short-duration intraarterial selective cooling infusion (IA-SCI) …

Background and Purpose—We conducted a pilot feasibility and safety study of selective
brain cooling with intra-arterial infusion of cold saline combined with endovascular …

This review examines the fundamentals and challenges in engineering/understanding the
thermostability of biological systems over a wide temperature range (from the cryogenic to …

BACKGROUND AND PURPOSE: Endovascular brain cooling as a method for rapid and
selective induction of hypothermic neuroprotection has not been systematically studied in …

Selective endovascular hypothermia has been used to provide cooling-induced cerebral
neuroprotection, but current catheters do not support thermally-insulated transfer of cold …

Therapeutic hypothermia (TH) is considered to improve survival with favorable neurological
outcome in the case of global cerebral ischemia after cardiac arrest and perinatal asphyxia …

This paper describes a modeling method of the tissue temperature evolution over time in
hyper or hypothermia. The tissue temperature evolution over time is classically described by …

Over decades, nearly all attempts to translate the benefits of therapeutic hypothermia in
stroke models of lower-order species to stroke patients have failed. Potentially overlooked …