Clostridioides difficile is the most common cause of nosocomial antibiotic-associated
diarrhea, and is responsible for a spectrum of diseases characterized by high levels of …

Antimicrobial resistance (AMR) in Clostridioides difficile remains a significant threat to global
healthcare systems, not just for the treatment of C. difficile infection (CDI), but as a reservoir …

Recently, the recommendations for the treatment of Clostridioides difficile infection (CDI)
have been updated. However, in addition to the clinical efficacy data, the drug of choice …

Antimicrobial resistance to treatments for Clostridioides difficile infection (CDI) poses a
significant threat to global health. C. difficile is widely thought to be susceptible to oral …

Highlights•Plasmid mediated resistances to metronidazole (pCD-METRO) and vancomycin
(pX18-498) may reduce their efficacies.•Heme-dependent resistance to metronidazole found …

Antimicrobial resistance (AMR) is a complex issue requiring specific, multi-sectoral
measures to slow its spread. When people are exposed to antimicrobial agents, it can cause …

Clostridioides difficile infection (CDI) is a leading cause of hospital-acquired diarrhea, which
often stems from disruption of the gut microbiota by broad-spectrum antibiotics. The …

Clostridioides difficile is the most important cause of healthcare-associated diarrhea in the
United States. The high incidence and recurrence rates of C. difficile infection (CDI) …

Objectives To determine the frequencies and clonal distributions of putative genetic
determinants of resistance to antimicrobials applied for treatment of Clostridioides difficile …

Highlights•C. difficile peptidoglycan is highly deacetylated.•C. difficile peptidoglycan
contains a majority of A 2 pm 3→ A 2 pm 3 cross-links.•C. difficile peptidoglycan is modified …