Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Adipose tissues display a remarkable ability to adapt to the dietary status. Here, we have
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

ATP citrate lyase (ACLY) is an important enzyme linking carbohydrate to lipid metabolism by
generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis. Mendelian …

Quantitative subcellular metabolomic measurements can explain the roles of metabolites in
cellular processes but are subject to multiple confounding factors. We developed stable …

Abstract mTORC2 phosphorylates AKT in a hydrophobic motif site that is a biomarker of
insulin sensitivity. In brown adipocytes, mTORC2 regulates glucose and lipid metabolism …

Adipose tissue signals to brain, liver, and muscles to control whole body metabolism through
secreted lipid and protein factors as well as neurotransmission, but the mechanisms …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal
cancers, with a five-year survival rate of around 5% to 8%. To date, very few available drugs …