Anti-inflammatory action of statins in cardiovascular disease: the role of inflammasome and toll-like receptor pathways
K Koushki, SK Shahbaz, K Mashayekhi… - Clinical reviews in …, 2021 - Springer
Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …
Berberine as a natural modulator of inflammatory signaling pathways in the immune system: Focus on NF‐κB, JAK/STAT, and MAPK signaling pathways
SM Haftcheshmeh, M Abedi… - Phytotherapy …, 2022 - Wiley Online Library
Three main inflammatory signaling pathways include nuclear factor‐κB (NF‐κB), Janus
kinases/Signal transducer and activator of transcriptions (JAKs/STATs), and mitogen …
kinases/Signal transducer and activator of transcriptions (JAKs/STATs), and mitogen …
Macrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery
Y Diao, D Liu, H Ge, R Zhang, K Jiang, R Bao… - Nature …, 2023 - nature.com
Interest in macrocycles as potential therapeutic agents has increased rapidly.
Macrocyclization of bioactive acyclic molecules provides a potential avenue to yield novel …
Macrocyclization of bioactive acyclic molecules provides a potential avenue to yield novel …
Gold nanoparticles: multifaceted roles in the management of autoimmune disorders
K Koushki, S Keshavarz Shahbaz, M Keshavarz… - Biomolecules, 2021 - mdpi.com
Gold nanoparticles (GNPs) have been recently applied for various diagnostic and
therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative …
therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative …
Effects of statins on myocarditis: a review of underlying molecular mechanisms
Myocarditis refers to the clinical and histological characteristics of a diverse range of
inflammatory cellular pathophysiological conditions which result in cardiac dysfunction …
inflammatory cellular pathophysiological conditions which result in cardiac dysfunction …
Evaluating the effect of LPS from periodontal pathogenic bacteria on the expression of senescence‐related genes in human dental pulp stem cells
The human dental pulp stem cells (hDPSCs) are one of the readily available sources of
multipotent mesenchymal stem cells (MSCs) and can be considered as a type of tool cells …
multipotent mesenchymal stem cells (MSCs) and can be considered as a type of tool cells …
A facile and high-sensitive bio-sensing of the V617F mutation in JAK2 gene by GSH-CdTe-QDs FRET-based sensor
This study aimed to directly detect the V617F point mutation of the Janus kinase 2 (JAK2)
gene in the target DNA using a FRET-based biosensor. The water-soluble GSH-CdTe-QDs …
gene in the target DNA using a FRET-based biosensor. The water-soluble GSH-CdTe-QDs …
Designing a new dimerized anti human TNF‐α aptamer with blocking activity
The human tumor necrosis factor α (hTNF‐α) is an important pro‐inflammatory cytokine
which plays critical roles in inflammatory diseases such as rheumatoid arthritis (RA). The …
which plays critical roles in inflammatory diseases such as rheumatoid arthritis (RA). The …
Macrocyclization Strategy for Improving Candidate Profiles in Medicinal Chemistry
Macrocycles are defined as cyclic compounds with 12 or more members. In medicinal
chemistry, they are categorized based on their core chemistry into cyclic peptides and …
chemistry, they are categorized based on their core chemistry into cyclic peptides and …
Quercetin, a key active ingredient of Jianpi Zishen Xiehuo Formula, suppresses M1 macrophage polarization and platelet phagocytosis by inhibiting STAT3 activation …
W Wang, X Xu, Y Xu, Y Zhan, C Wu, X Xiao… - Naunyn-Schmiedeberg's …, 2024 - Springer
Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease, and
abnormal M1 macrophage polarization participates in the pathogenesis of ITP. Jianpi Zishen …
abnormal M1 macrophage polarization participates in the pathogenesis of ITP. Jianpi Zishen …