Urate homeostasis in humans is a complex and highly heritable process that involves ie,
metabolic urate biosynthesis, renal urate reabsorption, as well as renal and extrarenal urate …

The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was
originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have …

Introduction Interindividual differences in drug response are a frequent clinical challenge
partly due to variation in pharmacokinetics. ATP-binding cassette (ABC) transporters are …

Gout is the most prevalent form of inflammatory arthritis, with a strong impact on individual
health and healthcare systems. This article reviews clinical and experimental evidences …

The ABCG2 protein has a key role in the transport of a wide range of structurally dissimilar
endo‐and xenobiotics in the human body, especially in the tissue barriers and the …

Background Currently, it is not possible to predict whether patients with hyperuricemia
(HUA) will develop gout and how this progression may be affected by urate-lowering …

Gout is a chronic metabolic disease that seriously affects human health. It is also a major
challenge facing the world, which has brought a heavy burden to patients and society …

Two-thirds of urate is excreted via the renal pathway and the remaining one-third via the
extra-renal pathway, the latter mainly via the intestine in healthy individuals. ABCG2, a urate …

Hyperuricemia and gout are metabolic diseases characterized with high serum urate and
impact human health significantly. Although some drugs have been developed to treat gout …

Urate transporters, which are located in the kidneys, significantly affect the level of uric acid
in the body. We looked at genetic variants of genes encoding the major reabsorption …