The cells and tissues of the human body are constantly exposed to exogenous and
endogenous forces that are referred to as biomechanical cues. They guide and impact …

Musculoskeletal tissues are constantly under mechanical strains within their
microenvironment. Yet, little is understood about the effect of in vivo mechanical milieu …

Endothelial cells (ECs) are continuously exposed in vivo to cyclic strain and shear stress
from pulsatile blood flow. When these stimuli are applied in vitro, ECs adopt an appearance …

Hemodynamic stresses are presumed to play an important role in the development of calcific
aortic valve disease (CAVD). The elucidation of the shear stress mechanisms involved in the …

Endothelial cell (EC) morphology and functions can be highly impacted by the mechanical
stresses that the cells experience in vivo. In most areas in the vasculature, ECs are …

We report a medium throughput device to study the effects of combinations of two
mechanical stimuli–surface strains and fluid flow shear stresses, on cells. The first …

Tenocyte mechanotransduction has been of great interest to researchers in tendon
mechanobiology and biomechanics. In vivo, tenocytes are subjected to tensile strain and …

Mechanical signals offer a promising way to control cell and tissue development. It has been
established that cells constantly probe their mechanical microenvironment and employ force …

Stem cell research grows rapidly in recent years due to its potential in clinical applications.
Since the stem cell behavior is influenced by environmental cues, investigation of the stem …

Native arteriovenous fistulas have a high failure rate mainly due to the lack of maturation
and uncontrolled neo-intimal hyperplasia development. Newly established hemodynamics …