New insights into the machinery of blood digestion by ticks

D Sojka, Z Franta, M Horn, CR Caffrey, M Mareš… - Trends in …, 2013 - cell.com
Blood-protein digestion is a key physiological process providing essential nutrients for ticks
and is a prerequisite for the transmission of tick-borne pathogens. Recently, substantial …

Proteases of haematophagous arthropod vectors are involved in blood-feeding, yolk formation and immunity-a review

PB Santiago, CN de Araújo, FN Motta, YR Praça… - Parasites & vectors, 2017 - Springer
Ticks, triatomines, mosquitoes and sand flies comprise a large number of haematophagous
arthropods considered vectors of human infectious diseases. While consuming blood to …

Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics

M Horn, M Nussbaumerová, M Šanda, Z Kovářová… - Chemistry & biology, 2009 - cell.com
Hemoglobin digestion is an essential process for blood-feeding parasites. Using chemical
tools, we deconvoluted the intracellular hemoglobinolytic cascade in the tick Ixodes ricinus …

Identification of protective antigens for the control of Ixodes scapularis infestations using cDNA expression library immunization

C Almazán, KM Kocan, DK Bergman, JC Garcia-Garcia… - Vaccine, 2003 - Elsevier
Identification of antigens that induce an immune response against tick infestations is
required for the development of vaccines against these economically important …

Molecular cloning and functional characterization of an aspartic protease from the hard tick Haemaphysalis longicornis

D Boldbaatar, CS Sikasunge, B Battsetseg… - Insect Biochemistry and …, 2006 - Elsevier
Haemaphysalis longicornis cDNA encoding an aspartic protease (longepsin) was identified
from a midgut cDNA library. The longepsin cDNA contains 1176bp that code for 392 amino …

Protein profiling of hemolymph in Haemaphysalis flava ticks

L Liu, F Yan, L Zhang, Z Wu, D Duan, T Cheng - Parasites & Vectors, 2022 - Springer
Background Tick hemolymph bathes internal organs, acts as an exchange medium for
nutrients and cellular metabolites, and offers protection against pathogens. Hemolymph is …

Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases

D Sojka, Z Franta, M Horn, O Hajdušek, CR Caffrey… - Parasites & vectors, 2008 - Springer
Background Ticks are vectors for a variety of viral, bacterial and parasitic diseases in human
and domestic animals. To survive and reproduce ticks feed on host blood, yet our …

[PDF][PDF] Generation and characterization of cDNA clones from Sarcoptes scabiei var. hominis for an expressed sequence tag library: identification of homologues of …

K Fischer, DC Holt, P Harumal, BJ Currie… - American Journal of …, 2003 - researchgate.net
Molecular studies on scabies, a disease of considerable human and veterinary significance,
have been limited because of the difficulty of obtaining the causative organism Sarcoptes …

Cathepsin L function in insect moulting: molecular cloning and functional analysis in cotton bollworm, Helicoverpa armigera

J Liu, GP Shi, WQ Zhang, GR Zhang… - Insect Molecular …, 2006 - Wiley Online Library
Moulting is an essential process of insect development but little is known about cysteine
proteases in the process. Here, we detail a proteolytic activity profile from fifth larval instar to …

IrAE–An asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus

D Sojka, O Hajdušek, J Dvořák, M Sajid… - International journal for …, 2007 - Elsevier
Ticks are ectoparasitic blood-feeders and important vectors for pathogens including
arboviruses, rickettsiae, spirochetes and protozoa. As obligate blood-feeders, one possible …