Introduction: The voltage-dependent potassium channel Kv1. 3 is mainly present in the
nervous and immune systems. In leukocytes, Kv1. 3 fine-tunes the activation and …

The voltage-gated potassium channel KV 1.3 is a well-established therapeutic target for a
range of autoimmune diseases, in addition to being the site of action of many venom-derived …

Microglia are highly plastic cells that can assume different phenotypes in response to
microenvironmental signals. Lipopolysaccharide (LPS) and interferon‐γ (IFN‐γ) promote …

Abstract The KV1. 3 voltage‐gated potassium ion channel is involved in many physiological
processes both at the plasma membrane and in the mitochondria, chiefly in the immune and …

Voltage-gated potassium channels play a key role in human physiology and pathology.
Reflecting their importance, numerous channelopathies have been characterised that arise …

Inflammation of the human vasculature is a manifestation of many different diseases ranging
from systemic autoimmune diseases to chronic inflammatory diseases, in which multiple …

Effector memory T lymphocytes (T EM cells) that lack expression of CCR7 are major drivers
of inflammation in a number of autoimmune diseases, including multiple sclerosis and …

Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic
inflammation. Immune dysfunction is an essential mechanism in the pathogenesis of RA and …

Simple Summary Ion channels are proteins that control the movement of ions across the
membranes of cells, thus regulating their physiological functions. In T lymphocytes, ion …

Increased expression of the voltage-gated potassium channel Kv1. 3 in activated microglia,
and the subsequent release of pro-inflammatory mediators, are closely associated with the …