Two-component systems reprogramme diverse aspects of microbial physiology in response
to environmental cues. Canonical systems are composed of a transmembrane sensor …

Motile Escherichia coli cells track gradients of attractant and repellent chemicals in their
environment with transmembrane chemoreceptor proteins. These receptors operate in …

Highlights•Classically, allostery induces a functional switch through a conformational
change.•Lately numerous studies concluded that allostery takes place through …

Allosteric and transmembrane (TM) signaling are among the major questions of structural
biology. Here, we review and discuss signal transduction in four‐helical TM bundles …

In this study, we present a conformational landscape of 5000 AlphaFold2 models of the
Histidine kinases, Adenyl cyclases, Methyl‐accepting proteins and Phosphatases (HAMP) …

Stable surface adhesion of cells is one of the early pivotal steps in bacterial biofilm
formation, a prevalent adaptation strategy in response to changing environments. In …

Modular proteins possess N-terminal sensor domains connected with different C-terminal
output domains. Different output domains, for example, phosphodiesterases adenylyl …

Coiled coils appear in countless structural contexts, as appendages to small proteins, as
parts of multi-domain proteins, and as building blocks of filaments. Although their structure is …

In a commonly accepted model, in response to stimuli, bacterial histidine kinases undergo a
conformational transition between an active and inactive form. Structural information on …

The randomization and screening of combinatorial DNA libraries is a powerful technique for
understanding sequence–function relationships and optimizing biosynthetic pathways …