The aim of this study was to investigate the Elsholtzia Stauntonii Benth. and Elsholtzia ciliate
Thun. dry extracts acute toxity, anti-inflammatory and analgesic activity. Phytochemical …

Background The pathophysiology behind the subacute but persistent hypercoagulable state
after traumatic brain injury (TBI) is poorly understood but contributes to morbidity induced by …

Low efficacy mu opioid receptor (MOR) agonists may serve as novel candidate analgesics
with improved safety relative to high-efficacy opioids. This study used a recently validated …

ABSTRACT Preclinical Research The aim of the present study was to evaluate the
antinoceptive interaction between the opioid analgesic, tapentadol, and the NSAID …

Abstract Preclinical Research & Development The purpose of this study was to assess the
interaction and mechanisms of action of the paracetamol‐tapentadol combination in the …

The purpose of this study was to evaluate the antinociceptive interaction between
dexketoprofen and tapentadol in three different dose ratios, as well as the ulcerogenic …

Psoriasis pain is a common symptom underestimated and rarely evaluated in psoriasis
clinical trials. This work aimed to investigate whether the development of secondary chronic …

Different NSAIDs are used as antinociceptive in various analgesic assays, among which
should be mentioned: ibuprofen, ketorolac, ketoprofen, meloxicam, paracetamol and others …

Abstract Preclinical Research & Development The objective of the present study was to
evaluate the tapentadol–diclofenac combination in three dose‐ratios in the mouse acetic …

In the treatment of acute and chronic pain the most frequently used drugs are nonsteroidal
anti-inflammatory drugs (NSAIDs), eg, paracetamol; opioids, eg, tramadol, and a group of …