Donor-derived cell-free DNA as a diagnostic tool in transplantation

M Oellerich, K Budde, B Osmanodja… - Frontiers in …, 2022 - frontiersin.org
There is a need to improve personalized immunosuppression in organ transplantation to
reduce premature graft loss. Biomarkers are needed to better detect rejection, asymptomatic …

miRNAs, dd-cf-DNA, and Chemokines as Potential Noninvasive Biomarkers for the Assessment of Clinical Graft Evolution and Personalized Immunosuppression …

O Millán, J Julian, M Brunet - Therapeutic Drug Monitoring, 2025 - journals.lww.com
The use of noninvasive biomarkers may reduce the need for biopsy and guide
immunosuppression adjustments during transplantation. The scientific community in solid …

Molecular monitoring of lung allograft health: is it ready for routine clinical use?

P Pradère, A Zajacova, S Bos… - European Respiratory …, 2023 - Eur Respiratory Soc
Maintenance of long-term lung allograft health in lung transplant recipients (LTRs) requires
a fine balancing act between providing sufficient immunosuppression to reduce the risk of …

All That Glitters in cfDNA Analysis Is Not Gold or Its Utility Is Completely Established Due to Graft Damage: A Critical Review in the Field of Transplantation

V Jiménez-Coll, J El kaaoui El band, S Llorente… - Diagnostics, 2023 - mdpi.com
In kidney transplantation, a biopsy is currently the gold standard for monitoring the
transplanted organ. However, this is far from an ideal screening method given its invasive …

Donor-derived cell-free DNA as a marker of graft injury after solid organ transplantation

M Oellerich, K Budde, K Bornemann-Kolatzki… - Therapeutic Drug …, 2024 - Elsevier
Transplant patients often suffer graft rejection. Chronic allograft dysfunction can result from
multiple both immunologic and nonimmunologic causes. Immunologic causes include acute …

A Hospitable Home? Cell-Free DNA and the Inflammatory Milieu in Lung Transplant Candidates

AJ Trindade - American Journal of Respiratory and Critical Care …, 2024 - atsjournals.org
Lung transplant recipients have experienced an improvement in survival over the last
decade due to advancements in donor procurement, surgical techniques, and medical …

Single center study investigating the clinical association of donor-derived cell-free DNA with acute outcomes in lung transplantation

K Noda, ME Snyder, Q Xu, D Peters… - Frontiers in …, 2024 - frontiersin.org
Background Circulating donor-derived cell-free DNA (dd-cfDNA) levels have been proposed
as a potential tool for the diagnosis of graft injury. In this study, we prospectively investigated …