3D bioprinting of tissues and organs
SV Murphy, A Atala - Nature biotechnology, 2014 - nature.com
Additive manufacturing, otherwise known as three-dimensional (3D) printing, is driving
major innovations in many areas, such as engineering, manufacturing, art, education and …
major innovations in many areas, such as engineering, manufacturing, art, education and …
Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
[HTML][HTML] High-throughput screening enhances kidney organoid differentiation from human pluripotent stem cells and enables automated multidimensional …
SM Czerniecki, NM Cruz, JL Harder, R Menon, J Annis… - Cell stem cell, 2018 - cell.com
Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-
throughput screening (HTS), but the complexity of organoid cultures poses a significant …
throughput screening (HTS), but the complexity of organoid cultures poses a significant …
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
A Rezania, JE Bruin, P Arora, A Rubin… - Nature …, 2014 - nature.com
Transplantation of pancreatic progenitors or insulin-secreting cells derived from human
embryonic stem cells (hESCs) has been proposed as a therapy for diabetes. We describe a …
embryonic stem cells (hESCs) has been proposed as a therapy for diabetes. We describe a …
Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro
Directed differentiation of human pluripotent stem cells into functional insulin‐producing
beta‐like cells holds great promise for cell replacement therapy for patients suffering from …
beta‐like cells holds great promise for cell replacement therapy for patients suffering from …
3D bioprinting in tissue engineering for medical applications: the classic and the hybrid
Three-dimensional (3D) printing, as one of the most popular recent additive manufacturing
processes, has shown strong potential for the fabrication of biostructures in the field of tissue …
processes, has shown strong potential for the fabrication of biostructures in the field of tissue …
Maturation of human embryonic stem cell–derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice
Diabetes is a chronic debilitating disease that results from insufficient production of insulin
from pancreatic β-cells. Islet cell replacement can effectively treat diabetes but is currently …
from pancreatic β-cells. Islet cell replacement can effectively treat diabetes but is currently …
Pluripotent stem cells in regenerative medicine: challenges and recent progress
After years of incremental progress, several recent studies have succeeded in deriving
disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect …
disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect …
Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines
Human pluripotent stem cells (hPSCs) represent a renewable source of pancreatic beta
cells for both basic research and therapeutic applications. Given this outstanding potential …
cells for both basic research and therapeutic applications. Given this outstanding potential …
Next-generation regenerative medicine: organogenesis from stem cells in 3D culture
Y Sasai - Cell stem cell, 2013 - cell.com
The behavior of stem cells, when they work collectively, can be much more sophisticated
than one might expect from their individual programming. This Perspective covers recent …
than one might expect from their individual programming. This Perspective covers recent …