Regulatory mechanism of MicroRNA expression in cancer

Z Ali Syeda, SSS Langden, C Munkhzul, M Lee… - International journal of …, 2020 - mdpi.com
Altered gene expression is the primary molecular mechanism responsible for the
pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are …

Glucocorticoids—all-rounders tackling the versatile players of the immune system

C Strehl, L Ehlers, T Gaber, F Buttgereit - Frontiers in immunology, 2019 - frontiersin.org
Glucocorticoids regulate fundamental processes of the human body and control cellular
functions such as cell metabolism, growth, differentiation, and apoptosis. Moreover …

MicroRNA: biogenesis, function and role in cancer

LA MacFarlane, PR Murphy - Current genomics, 2010 - ingentaconnect.com
MicroRNAs are small, highly conserved non-coding RNA molecules involved in the
regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III …

miR‐223: infection, inflammation and cancer

M Haneklaus, M Gerlic, LAJ O'Neill… - Journal of internal …, 2013 - Wiley Online Library
Expression of the micro RNA miR‐223 is deregulated during influenza or hepatitis B
infection and in inflammatory bowel disease, type 2 diabetes, leukaemia and lymphoma …

[HTML][HTML] New dimension of glucocorticoids in cancer treatment

KT Lin, LH Wang - Steroids, 2016 - Elsevier
Glucocorticoids have been used in clinical oncology for over half a century. The clinical
applications of glucocorticoids in oncology are mainly dependent on their pro-apoptotic …

Leukaemogenesis: more than mutant genes

J Chen, O Odenike, JD Rowley - Nature Reviews Cancer, 2010 - nature.com
Acute leukaemias are characterized by recurring chromosomal aberrations and gene
mutations that are crucial to disease pathogenesis. It is now evident that epigenetic …

MicroRNAs: predictors and modifiers of chemo-and radiotherapy in different tumour types

R Hummel, DJ Hussey, J Haier - European journal of cancer, 2010 - Elsevier
MicroRNAs (miRNAs) represent a class of naturally occurring small non-coding RNA
molecules. They regulate gene expression at the post-transcriptional level and control …

Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases

IME Beck, W Vanden Berghe, L Vermeulen… - Endocrine …, 2009 - academic.oup.com
Glucocorticoids (GCs) are steroidal ligands for the GC receptor (GR), which can function as
a ligand-activated transcription factor. These steroidal ligands and derivatives thereof are …

Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids

J Wu, C Zheng, Y Fan, C Zeng, Z Chen… - Journal of the …, 2014 - journals.lww.com
MicroRNAs (miRNAs) are essential for podocyte homeostasis, and the miR-30 family may
be responsible for this action. However, the exact roles and clinical relevance of miR-30s …

Clinical significance of microRNAs in chronic and acute human leukemia

CH Yeh, R Moles, C Nicot - Molecular cancer, 2016 - Springer
Small non-coding microRNAs (miRNAs) are epigenetic regulators that target specific cellular
mRNA to modulate gene expression patterns and cellular signaling pathways. miRNAs are …