Next generation gold drugs and probes: chemistry and biomedical applications

RT Mertens, S Gukathasan, AS Arojojoye… - Chemical …, 2023 - ACS Publications
The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

Molecular mechanisms and clinical implications of the gold drug auranofin

S Shen, J Shen, Z Luo, F Wang, J Min - Coordination Chemistry Reviews, 2023 - Elsevier
Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …

[HTML][HTML] The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells

HA Rothan, S Stone, J Natekar, P Kumari, K Arora… - Virology, 2020 - Elsevier
SARS-COV-2 has recently emerged as a new public health threat. Herein, we report that the
FDA-approved drug, auranofin, inhibits SARS-COV-2 replication in human cells at low micro …

[HTML][HTML] Auranofin: Past to Present, and repurposing

M Yamashita - International Immunopharmacology, 2021 - Elsevier
Auranofin (AF), a gold compound, has been used to treat rheumatoid arthritis (RA) for more
than 40 years; however, its mechanism of action remains unknown. We revealed that AF …

[HTML][HTML] Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress

S Renken, T Nakajima, I Magalhaes… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Adoptive cell therapy using cytotoxic lymphocytes is an efficient immunotherapy
against solid and hematological cancers. However, elevated levels of reactive oxygen …

HIV-1 latency and viral reservoirs: existing reversal approaches and potential technologies, targets, and pathways involved in HIV latency studies

S Khanal, M Schank, M El Gazzar, JP Moorman… - Cells, 2021 - mdpi.com
Eradication of latent human immunodeficiency virus (HIV) infection is a global health
challenge. Reactivation of HIV latency and killing of virus-infected cells, the so-called “kick …

Glycolysis downregulation is a hallmark of HIV‐1 latency and sensitizes infected cells to oxidative stress

IL Shytaj, FA Procopio, M Tarek… - EMBO molecular …, 2021 - embopress.org
HIV‐1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir
responsible for maintaining lifelong infection. Glycolytic metabolism has been identified as a …

Metal-based complexes against SARS-CoV-2

K Ioannou, MC Vlasiou - Biometals, 2022 - Springer
The first appearance of SARS-CoV-2 is dated back to 2019. This new member of the
coronavirus family has caused more than 5 million deaths worldwide up until the end of …

Functional utility of gold complexes with phosphorus donor ligands in biological systems

AS Arojojoye, SG Awuah - Coordination Chemistry Reviews, 2025 - Elsevier
Metallo-phosphines are ubiquitous in organometallic chemistry with widespread
applications as catalysts in various chemical transformations, precursors for organic …

A Comprehensive survey on the expediated anti-COVID-19 options enabled by metal complexes—Tasks and trials

J Gopal, M Muthu, I Sivanesan - Molecules, 2023 - mdpi.com
Contemporary pharmacology dating back to the late 19th/early 20th centuries has benefitted
largely from the incorporation of metal complexes. Various biological attributes have been …