The mechanisms underlying the selective targeting of specific brain regions by different
neurodegenerative diseases is one of the most intriguing mysteries in medicine. For …

Since the term protein was first coined in 1838 and protein was discovered to be the
essential component of fibrin and albumin, all cellular proteins were presumed to play …

The four glycoforms of the cellular prion protein (PrPC) variably glycosylated at the two N-
linked glycosylation sites are converted into their pathological forms (PrPSc) in most cases …

Mammalian prion or PrPSc is a proteinaceous infectious agent that consists of a misfolded,
self-replicating state of the prion protein or PrPC. PrPC and PrPSc are posttranslationally …

Prion diseases are associated with the conformational conversion of the cellular prion
protein (PrPC) into the pathological scrapie isoform (PrPSc) in the brain. Both the in vivo and …

Prion is an infectious protein (PrPSc) that is derived from a cellular glycoprotein (PrPC)
through a conformational transition and associated with a group of prion diseases in animals …

Delineation of the effects of pathogenic mutations linked with familial prion diseases on the
structure and misfolding of prion protein (PrP) will be useful in understanding the molecular …

Both sporadic variably protease-sensitive prionopathy (VPSPr) and familial Creutzfeldt-
Jakob disease linked to the prion protein (PrP) V180I mutation (fCJD V180I) have been …

Insertion of 144-base pair (bp) containing six extra octapeptide repeats between residues 51
and 91 of prion protein (PrP) gene is associated with inherited prion diseases. Most cases …

Unlike other human prion diseases, including the most common Creutzfeldt–Jakob disease
(CJD), variably protease-sensitive prionopathy (VPSPr) is characterized by the deposition of …