Beyond horizontal gene transfer: the role of plasmids in bacterial evolution

J Rodríguez-Beltrán, J DelaFuente… - Nature Reviews …, 2021 - nature.com
Plasmids have a key role in bacterial ecology and evolution because they mobilize
accessory genes by horizontal gene transfer. However, recent studies have revealed that …

Mobile genetic elements associated with antimicrobial resistance

SR Partridge, SM Kwong, N Firth… - Clinical microbiology …, 2018 - Am Soc Microbiol
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …

Bacteria have numerous distinctive groups of phage–plasmids with conserved phage and variable plasmid gene repertoires

E Pfeifer, JA Moura de Sousa, M Touchon… - Nucleic acids …, 2021 - academic.oup.com
Plasmids and temperate phages are key contributors to bacterial evolution. They are usually
regarded as very distinct. However, some elements, termed phage–plasmids, are known to …

The Standard European Vector Architecture (SEVA): a coherent platform for the analysis and deployment of complex prokaryotic phenotypes

R Silva-Rocha, E Martínez-García, B Calles… - Nucleic acids …, 2013 - academic.oup.com
Abstract The 'Standard European Vector Architecture'database (SEVA-DB, http://seva. cnb.
csic. es) was conceived as a user-friendly, web-based resource and a material clone …

Biological foundations of successful bacteriophage therapy

C Venturini, A Petrovic Fabijan… - EMBO Molecular …, 2022 - embopress.org
Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous
in nature, phages can be used to treat bacterial infections (phage therapy), including …

[HTML][HTML] Mathematical models of plasmid population dynamics

JCR Hernández-Beltrán, A San Millán… - Frontiers in …, 2021 - frontiersin.org
With plasmid-mediated antibiotic resistance thriving and threatening to become a serious
public health problem, it is paramount to increase our understanding of the forces that …

[HTML][HTML] Bacterial partition complexes segregate within the volume of the nucleoid

A Le Gall, DI Cattoni, B Guilhas… - Nature …, 2016 - nature.com
Precise and rapid DNA segregation is required for proper inheritance of genetic material. In
most bacteria and archaea, this process is assured by a broadly conserved mitotic-like …

[HTML][HTML] Stochastic self-assembly of ParB proteins builds the bacterial DNA segregation apparatus

A Sanchez, DI Cattoni, JC Walter, J Rech… - Cell systems, 2015 - cell.com
Many canonical processes in molecular biology rely on the dynamic assembly of higher-
order nucleoprotein complexes. In bacteria, the assembly mechanism of ParABS, the …

SMC is recruited to oriC by ParB and promotes chromosome segregation in Streptococcus pneumoniae

A Minnen, L Attaiech, M Thon, S Gruber… - Molecular …, 2011 - Wiley Online Library
Segregation of replicated chromosomes is an essential process in all organisms. How
bacteria, such as the oval‐shaped human pathogen Streptococcus pneumoniae, efficiently …

Mechanisms of plasmid segregation: have multicopy plasmids been overlooked?

S Million-Weaver, M Camps - Plasmid, 2014 - Elsevier
Plasmids are self-replicating pieces of DNA typically bearing non-essential genes. Given
that plasmids represent a metabolic burden to the host, mechanisms ensuring plasmid …