The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …

Abstract Phosphatidylinositol (4, 5) bisphosphate (PI (4, 5) P2) has become a major focus in
biochemistry, cell biology and physiology owing to its diverse functions at the plasma …

Alzheimer's disease (AD) is characterized by the presence of amyloid β (Aβ) plaques, tau
tangles, inflammation, and loss of cognitive function. Genetic variation in a cholesterol …

Lipids play important modulatory and structural roles for membrane proteins. Molecular
dynamics simulations are frequently used to provide insights into the nature of these protein …

Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …

Coronavirus disease 2019 (COVID19) is a respiratory infection caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China in 2019 …

Inhaled anesthetics are a chemically diverse collection of hydrophobic molecules that
robustly activate TWIK-related K+ channels (TREK-1) and reversibly induce loss of …

Insects thrive in diverse ecological niches in large part because of their highly sophisticated
olfactory systems. Over the last two decades, a major focus in the study of insect olfaction …

Lipids play important roles in regulating membrane protein function, but the molecular
mechanisms used are elusive. Here we investigated how anionic lipids modulate SthK, a …

Neurodegeneration and its loss of cognitive function is associated with inflammation and an
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …